2069-47-8

Usage

Uses

Used in Pharmaceutical Development:
6-CHLORO-2-(4-FLUOROPHENYL)IMIDAZO[1,2-A]PYRIDINE is utilized as a potential therapeutic agent for the treatment of specific diseases or conditions. Its unique chemical structure and properties contribute to its pharmacological activities, which are currently under investigation for their efficacy and safety in clinical applications.
Used in Drug Discovery Research:
In the field of drug discovery, 6-CHLORO-2-(4-FLUOROPHENYL)IMIDAZO[1,2-A]PYRIDINE serves as a chemical probe to explore novel mechanisms of action and identify new targets for therapeutic intervention. Its study aids in understanding the molecular interactions and pathways relevant to various diseases, potentially leading to the development of innovative treatments.
Used in Medicinal Chemistry:
6-CHLORO-2-(4-FLUOROPHENYL)IMIDAZO[1,2-A]PYRIDINE is employed as a key intermediate in the synthesis of more complex molecules with enhanced therapeutic properties. Medicinal chemists use 6-CHLORO-2-(4-FLUOROPHENYL)IMIDAZO[1,2-A]PYRIDINE to modify and optimize its structure to improve pharmacokinetics, selectivity, and potency, thereby increasing the likelihood of successful drug development.

Upstream product

• 1072-98-6 5-chloro-2-pyridylamine 
• 403-29-2 2-bromo-4'-fluoroacetophenone 
• 329-79-3 1-(4-fluorophenyl)ethanone oxime 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 896885-34-0 1-(4-fluorophenyl)ethan-1-one-O-acetyl oxime 
• 54187-96-1 1-(chloromethyl)-1H-benzotriazole 
• 459-57-4 4-fluorobenzaldehyde 

Downstream Products

• 930113-36-3 C₁₈H₁₁ClFN₃ 
• 930113-35-2 C₁₈H₁₁ClFN₃ 

Relevant academic research and scientific papers

CuCl2-catalyzed N[sbnd]O bond cleavage of oxime esters: Approach to imidazoheterocycles and furo[3,2-c]chromenyl fused imidazoles

An articulate approach to a diverse set of imidazoheterocycles in good to high yields via a copper-catalyzed aza-annulation of several oxime esters with a group of 2-amino-azaarenes was developed. The above cyclization reaction probably proceeds via a single electron transfer process which embodies a new technique for creating two new C[sbnd]N bonds for imidazole ring synthesis. Gratifyingly, the implementation of this chemistry could be further stretched to the synthesis of a novel class of fused imidazoles bearing a furo[3,2-c]chromene moiety via a sequential C[sbnd]N bond formation, followed by C(sp2)-H functionalization/5-endo-dig-oxacyclization (C[sbnd]C and C[sbnd]O bonds) of in situ produced fused imidazoles with cyclic enynones in the presence of copper(II) as a π-electrophilic Lewis acid catalyst.

One-pot synthesis of 2-phenylimidazo[1,2-α]pyridines from acetophenone, [Bmim]Br3 and 2-aminopyridine under solvent-free conditions

One-pot synthesis of 2-phenylimidazo[1,2-α]pyridines from acetophenone, [Bmim]Br3 and 2-aminopyridine under solvent-free conditions in the presence of Na2CO3, gave the corresponding 2-phenylimidazo[1,2-α]pyridines in excel

Efficient syntheses of imidazolo[1,2-αa]pyridines and -[2,1-α]isoquinolines

2-Aminopyridines 1a-c and 1-aminoisoquinoline with 1-chloromethylbenzotriazole give 2-amino-1-[α-benzotriazol-1-ylmethyl]pyridinium chlorides 2a-c and 1-amino-2-(α-benzotriazol-1-ylmethyl)-isoquinolinium chloride 12, respectively. Compounds 2a-c and 12 react with aryl aldehydes 3a-h to afford imidazolo[1,2-α]pyridines 7a-k and imidazolo[2,1-α]isoquinolines 13a,b in good yields.