207129-88-2

Upstream product

• 100-59-4 phenylmagnesium chloride 
• 184370-65-8 {[(4-bromobut-3-yn-1-yl)oxy]methyl}benzene 
• 591-50-4 iodobenzene 
• 22273-77-4 ((but-3-yn-1-yloxy)methyl)benzene 
• 10229-11-5 4-phenyl-but-3-yn-1-ol 
• 100-39-0 benzyl bromide 
• 54555-84-9 benzyl iodoethyl ether 
• 536-74-3 phenylacetylene 

Downstream Products

• 6285-99-0 (E)-benzylidenedihydro-2(3H)-furanone 
• 13019-35-7 3-phenyl-5,6-dihydro-2H-pyran-2-one 
• 1120371-14-3 (E)-2-benzylidene-4-benzyloxy-1-(4-nitrophenyl)-butan-1-ol 
• 1318082-38-0 C₁₇H₁₆⁽²⁾H₂O 

Relevant academic research and scientific papers

Visible light promoted continuous flow photocyclization of 1,2-diketones

The continuous flow Norrish-Yang photocyclization of 1,2-diketones has been developed and used for the synthesis of a large number of functionalized 2-hydroxycyclobutanones, under blue light irradiation and employing acetone as a solvent. This eco-friendly procedure represents a valid alternative to the reactions carried out in batches thus reducing the reaction times, the formation of secondary products and simplifying the purification steps. The use of differently substituted diketone compounds has allowed us to obtain a wide range of 2 and 3-functionalized cyclobutanones, thus allowing the evaluation of the scope and limitations of this procedure.

A Study of Polarization and Directing Effects of Unsymmetrical Alkynes Using Regioselective Pd-Catalyzed Bromoallylation

Herein is disclosed the first comprehensive study of factors that affect the regioselectivity of PdBr2(PhCN)2-catalyzed bromoallylation of unsymmetrically substituted internal alkynes. The study was performed on a wide array of electronically and structurally diverse alkynes with aryl-aryl, aryl-ferrocenyl, and aryl-alkyl substitutions. The regioselective formation of bromoallylation products was mostly driven by the polarization of the triple bond in aryl-aryl and aryl-ferrocenyl-substituted ethynes. On the other hand, directing effect, which arises from the presence of a directing group in the side-chain of aryl-alkyl-substituted alkynes, was the dominating factor that determined the regioselectivity of these reactions.

Soft propargylic deprotonation: Designed ligand enables au-catalyzed isomerization of alkynes to 1,3-Dienes

By functionalizing the privileged biphenyl-2-ylphosphine with a basic amino group at the rarely explored 3′ position, the derived gold(I) complex possesses orthogonally positioned "push" and "pull" forces, which enable for the first time soft propargylic deprotonation and permit the bridging of a difference of >26 pKa units (in DMSO) between a propargylic hydrogen and a protonated tertiary aniline. The application of this design led to efficient isomerization of alkynes into versatile 1,3-dienes with synthetically useful scope under mild reaction conditions.

Rh(I)-catalyzed CO gas-free cyclohydrocarbonylation of alkynes with formaldehyde to α,β-butenolides

The rhodium(I)-catalyzed reaction of alkynes with formaldehyde proceeds via the double incorporation of a carbonyl moiety from formaldehyde, resulting in a CO gas-free cyclohydrocarbonylation leading to α,β-butenolides. The Royal Society of Chemistry 2005.

Novel decomplexation method for alkyne-Co2(CO)6 complexes

A novel and general decomplexation method for alkyne-Co2(CO)6 complexes has been established, which treats the complexes with ethylenediamine in THF.