46114-86-7

Usage

InChI:InChI=1/C9H9NO2/c1-7(11)9(12)10-8-5-3-2-4-6-8/h2-6H,1H3,(H,10,12)

Upstream product

• 7682-09-9 4-methyleneoxazolidine-2,5-dione 
• 62-53-3 aniline 
• 106942-22-7 lactanilide 
• 858273-56-0 2,4-dihydroxy-4-methyl-5-oxo-1-phenyl-pyrrolidine-2-carboxylic acid anilide 
• 52060-80-7 pyridinium 2,5-dihydro-2,5-dioxofuran-3-olate 
• 72681-61-9 4-methyl-2,2-bis-trifluoromethyl-2H-oxazol-5-one 
• 113-24-6 sodium pyruvate 
• 10026-13-8 phosphorus pentachloride 
• 7732-18-5 water 
• 110-86-1 pyridine 
• 113710-05-7 3-hydroxy-N-phenyl-maleamic acid 
• 127-17-3 2-oxo-propionic acid 
• 622-34-4 1-phenylcyanamide 
• 103-71-9 phenyl isocyanate 

Downstream Products

• 130594-37-5 2-hydroxyimino-propionic acid anilide 
• 858273-56-0 2,4-dihydroxy-4-methyl-5-oxo-1-phenyl-pyrrolidine-2-carboxylic acid anilide 
• 79878-72-1 2-oxo-4t-phenyl-but-3-enoic acid anilide 
• 7037-05-0 2-phenylhydrazono-propionic acid anilide 
• 57383-90-1 C₁₀H₁₄N₄O₃ 
• 65954-99-6 Pyruvanilidmethylimin 
• 90367-77-4 3-bromopyruvanilide 
• 106942-22-7 lactanilide 
• 90367-74-1 diethyl N-phenylphosphoenolpyruvamide 

Relevant academic research and scientific papers

Rapid assembly of α-ketoamides through a decarboxylative strategy of isocyanates with α-oxocarboxylic acids under mild conditions

A simple and practical method for α-ketoamide synthesis via a decarboxylative strategy of isocyanates with α-oxocarboxylic acids is described. The reaction proceeds at room temperature under mild conditions without an oxidant or an additive, showing good substrate scope and functional compatibility. Moreover, the applicability of this method was further demonstrated by the synthesis of various bioactive molecules and different application examples through a two-step one-pot operation.

Synthesis method of alpha-ketoamide compound

The invention discloses a synthesis method of an alpha-ketoamide compound. The preparation method comprises the following steps of: taking an isocyanate compound as shown in a formula I and a benzoylformic acid compound as shown in a formula II as raw mat

Synthetic method of alpha-keto amide compound

The invention discloses a synthesis method of an alpha-keto amide compound, which comprises the following steps: mixing a benzoyl azide compound as shown in a chemical formula I with a benzoyl formicacid compound as shown in a chemical formula II, and reacting to obtain an alpha-keto amide compound as shown in a chemical formula III; in the formula, R1 is a monosubstituted or polysubstituted group on a benzene ring; R2 is a group that is not H; the synthesis method can be used for efficiently synthesizing the functionalized alpha-ketoamide compound, has the advantages of simple synthesis steps, safety in operation, good compatibility of the synthesis method to functional groups and high atom economy, and is easy for industrial synthesis.

Alkyl keto-amide, amidoxime compound thereof, and preparation and application of compound

The invention relates to alkyl keto-amide, an amidoxime compound thereof, and preparation and application of the compound. The alkyl keto-amide compound and a derivative thereof can be applied to metal palladium catalyzed C-H bond fluoridation, better rea

Catalyst-free three-component synthesis of highly functionalized 2,3-dihydropyrroles

An efficient synthesis of fully substituted 2,3-dihydropyrroles has been achieved in one step through the three-component reaction of amines, aromatic aldehydes and α-ketoamides. This atom-economical and catalyst-free reaction is highly stereoselective and generates underexplored heterocycles in a single step. These compounds were examined in an enzymatic assay that led to the identification of potent α-glucosidase inhibitors, thereby demonstrating the utility of this novel methodology in medicinal chemistry.

Selective Carbonyl?C(sp3) Bond Cleavage To Construct Ynamides, Ynoates, and Ynones by Photoredox Catalysis

Carbon–carbon bond cleavage/functionalization is synthetically valuable, and selective carbonyl?C(sp3) bond cleavage/alkynylation presents a new perspective in constructing ynamides, ynoates, and ynones. Reported here is the first alkoxyl-radical-enabled carbonyl?C(sp3) bond cleavage/alkynylation reaction by photoredox catalysis. The use of novel cyclic iodine(III) reagents are essential for β-carbonyl alkoxyl radical generation from β-carbonyl alcohols, including alcohols with high redox potential (EoxP>2.2 V vs. SCE in MeCN). β-Amide, β-ester, and β-ketone alcohols yield ynamides, ynoates, and ynones, respectively, for the first time, with excellent regio- and chemoselectivity under mild reaction conditions.

Enantioselective Construction of 3-Hydroxypiperidine Scaffolds by Sequential Action of Light and Rhodium upon N-Allylglyoxylamides

3-Hydroxypiperidine scaffolds were enantioselectively constructed in an atom-economical way by sequential action of light and rhodium upon N-allylglyoxylamides. In a formal sense, the allylic C-H bond was selectively cleaved and enantioselectively added a

A temporary-bridge strategy for enantioselective organocatalyzed synthesis of aza-seven-membered rings

We report the first enantioselective organocatalyzed domino synthesis of azepane moieties. This temporary-bridge strategy is based on a conceptually original annulation of ambident electrophilic and 1,4-bis-nucleophilic α-ketoamides with 1,3-bis-electrophilic enals. The obtained oxygen-bridged azepanes can be selectively transformed into optically active azepanone, azepanol or azepanedione derivatives of high synthetic value. This journal is

A palladium(II)-catalyzed synthesis of α-ketoamides via chemoselective aroyl addition to cyanamides

An acyl moiety generated from α-oxocarboxylic acids via decarboxylation undergoes a palladium-catalyzed chemoselective insertion into organic cyanamides to afford N-monosubstituted α-ketoamides.

Oxygen-involved oxidative deacetylation of α-substituted β-acetyl amides - Synthesis of α-Keto amides

α-Substituted β-acetyl amides could undergo C-C bond cleavage to form α-keto amides when treated with copper(II) chloride (CuCl 2) and boron trifluoride diethyl etherate (BF3× OEt2) under an oxygen atmosphere. The yield can be increased by the addition of tert-butyl hydroperoxide which alone can also effect the reaction. The reaction provides a new protocol for the synthesis of α-keto amides. Copyright