20717-86-6

Usage

Uses

Used in Ceramic Industry:
CHLOROTITANIUM TRIISOPROPOXIDE is used as a precursor for the synthesis of ultralow density ceramic materials. Its role in the production process allows for the creation of ceramics with unique properties, such as low density and potentially enhanced performance characteristics.
Used in Chemical Synthesis:
CHLOROTITANIUM TRIISOPROPOXIDE is used as a mediator in chemical reactions, specifically for the reductive amination of 5α-cholestane-3,7-dione to yield aryl aminocholestanes. This application highlights its utility in organic synthesis, enabling the production of complex molecules with potential applications in various fields, such as pharmaceuticals or materials science.

Purification Methods

When distilled under vacuum, the distillate sets slowly to a solid on standing. Stock reagents are made by dissolving the warm liquid in pentane, toluene, Et2O, THF, CH2Cl2,, and can be stored in a pure state or in solution under dry N2 for several months. The reagent is hygroscopic and is hydrolysed by H2O. [Reetz et al. Chem Ber 118 1421 1985.]

InChI:InChI=1/3C3H7O.ClH.Ti/c3*1-3(2)4;;/h3*3H,1-2H3;1H;/q3*-1;;+4/p-1/rC9H21ClO3Ti/c1-7(2)11-14(10,12-8(3)4)13-9(5)6/h7-9H,1-6H3

Upstream product

• 546-68-9 titanium(IV) isopropylate 
• 7550-45-0 titanium tetrachloride 
• 16635-23-7 phenyltriisopropoxytitanium(IV) 
• 107-05-1 3-chloroprop-1-ene 
• 18610-33-8 (E)-4-chloropent-2-ene 
• 165824-72-6 Ti(OCH(CH₃)2)3(C₁₉H₂₁N₂O) 

Relevant academic research and scientific papers

Palladium-catalyzed cross-coupling of benzyltitanium(IV) reagents with aryl fluorides

The first palladium-catalyzed cross-coupling between benzyltitanium(IV) reagents with aryl fluorides is reported. A variety of diarylmethanes can be prepared in good to excellent yields by the catalyst system of PdCl2(dppf)2 associated with 1-[2-(di-tert-butylphosphanyl)phenyl]-4-methoxypiperidine. This reaction offered a highly efficient approach to diarylmethanes that are commonly found in life-changing drug molecules. Graphical abstract: [Figure not available: see fulltext.]

Method for Catalytic Enantioselective Alkylation of Aldehydes Using Grignard Reagents as Alkyl Sources

Alkyltitanium reagents, generated in situ from Grignard reagents and ClTi(OiPr)3, can be employed without further manipulation in the enantioselective alkylation of aldehyde by the catalysis of a chiral titanium complex derived from DTBP-H8-BINOL. The reaction is performed with good stoichiometry [1.5 equiv each of Grignard reagents and ClTi(OiPr)3] at a low catalyst loading (2 mol %), affording a variety of chiral secondary alcohols in high enantioselectivity and yields and, hence, realizing an asymmetric version of the Grignard reaction in an indirect manner.

Catalytic Enantioselective Arylation and Heteroarylation of Ketones with Organotitanium Reagents Generated In Situ

A practical and useful, catalytic enantioselective method has been developed for the synthesis of tertiary diaryl and aryl heteroaryl carbinols starting from commercially available aromatic ketones and aryl or heteroaryl bromides. In this method, organotitanium reagents are generated in situ from the bromides by lithiation with nBuLi followed by transmetallation of the resulting organolithiums with ClTi(OiPr)3. Treatment of the ketones with the titanium reagents in the presence of (R)-3-(3,5-bistrifluoromehthylphenyl)-1,1′-bi-2-naphthol (BTFP-BINOL) affords the corresponding tertiary alcohols in high enantioselectivities and yields. The reaction can also start with furan and 2-thienyllithium. The method is operationally simple and can be conducted on a 10-mmol scale without any difficulties.

GROUP 4 METAL COMPLEX, PRODUCTION METHOD THEREOF, PREPARATION METHOD OF GROUP 4 METAL-CONTAINING THIN FILM

PROBLEM TO BE SOLVED: To provide a group 4 metal complex having excellent thermal stability and proper vapor pressure and suitable as a material for preparing a group 4 metal-containing thin film. SOLUTION: There is provided the group 4 metal complex represented by the general formula (1), where M represents a group 4 metal atom, R1, R2, R3 and R4 each represent independently a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, R5, R6 and R7 each represent independently an alkyl group having 1 to 8 carbon atoms, R8, R9 and R10 each represent independently an alkyl group having 1 to 6 carbon atoms or a di (alkyl having 1 to 3 carbon atoms) amino group. SELECTED DRAWING: None COPYRIGHT: (C)2016,JPO&INPIT

Heating under high-frequency inductive conditions: Application to the continuous synthesis of the neurolepticum olanzapine (Zyprexa)

Hot chemistry! High-frequency inductive heating and flow chemistry are an ideal match for high-temperature synthesis. This is demonstrated in the multistep flow synthesis of the neurolepticum olanzapine (Zyprexa) that included three reactions with inductive heating and two purification steps conducted as continuous processes. Copyright

PROCESS FOR PRODUCING OPTICALLY ACTIVE ALCOHOL

Disclosed is a method for producing an optically active alcohol including reacting a titanium compound, an aromatic magnesium compound and a carbonyl compound in the presence of an optically active biphenol compound having a predetermined structure and an ether compound having a predetermined structure.

Molecular engineering of coordination pockets in chloro-tris-phenoxo complexes of titanium(IV)

The chloro-tris-phenoxo complexes [TiCl(OAr)3] (OAr = OC6H4CMe3-4 (1), OC6H3Me2-2,4 (2), OC6H2Me3-2,4,6 (4), OC6H3(CHMe2)2-2,6 (5), OC6H3(CMe3)2-2,4 (6) and OC6H4Ph-2 (8) are prepared by heating 3 equivalents of the phenol and [TiCl4] in toluene. X-ray crystal structure determinations show that 2 is a phenoxy-bridged dimer with the ortho-methyl groups making the beginning of a pocket about the terminal chloro ligand and 6 is a tetrahedral monomer in which the pocket is more well developed by the ortho-tert-butyl groups. Both 2 and 6 react with dmbipy to give [TiCl(OAr)3(dmbipy)] [OAr = OC6H3Me2-2,4 (3) and OC6H3(CMe3)2-2,4 (7)] in which the original pocket is destroyed. Reaction of TiCl4 with 3 equivalents of LiOC6H4Ph-2 in diethyl ether gives [TiCl(OC6H4Ph-2)3(diethyl ether)] (9) for which an X-ray crystal structure determination shows a trigonal bipyramidal coordination geometry with the diethyl ether lying trans to the chloro ligand. The three phenoxide ligands make up the equatorial plane which takes the 2-phenyl substituent on each phenoxo ligand away from the chloro ligand resulting in a partially collapsed cavity. The tied-back analogues of 2 and 6, [TiCl{(OC6H2Me2-2,4-CH2-6) 3N}] (11) and [TiCl({OC6H2(CMe3)2-2,4-CH 2-6}3N)] · diethyl ether (12), are prepared by adding (HOArCH2)3N [Ar = C6H2Me2-2,4 and C6H2(CMe3)2 2,4] to [TiCl(OCHMe2)3] in diethyl ether. An X-ray crystal structure of 12 showed a trigonal bipyramidal structure with a coordination environment about the terminal chloro ligand similar to that found in 6. Complex 12 reacts with pyridine to form the 6-coordinate complex [TiCl({OC6H2(CMe3)2-2,4-CH 2-6}3N)(py)] (13).

Titanium alkoxides as initiators for the controlled polymerization of lactide

Fourteen titanium alkoxides were synthesized for comparison of their catalytic properties in the bulk and solution polymerization of lactide (LA). In bulk polymerizations, they are effective catalysts in terms of polymer yield and molecular weight. Titanatranes gave polylactides with significantly increased molecular weight over more extended polymerization times, and those with five-membered rings afforded polymers in higher yields and with larger molecular weights than their six-membered ring counterparts. Steric hindrance of the rings was found to significantly affect polymer yields. Increased heterotactic-biased poly(rac-LA) was formed as the number of chlorine atoms increased in TiClx(O-i-Pr)4-x. In solution polymerizations, titanium alkoxides catalyzed controlled polymerizations of LA, and end group analysis demonstrated that an alkoxide substituent on the titanium atom acted as the initiator. That polymerization is controlled under our conditions was shown by the linearity of molecular weight versus conversion. A tendency toward formation of heterotactic-biased poly(rac-LA) was observed in the solution polymerizations. The rate of ring-opening polymerization (ROP) and the molecular weight of the polymers are greatly influenced by the substituents on the catalyst, as well as by factors such as the polymerization temperature, polymerization time, and concentration of monomer and catalyst.

Method for preparing cyclopropylamines

PCT No. PCT/EP97/06100 Sec. 371 Date May 6, 1999 Sec. 102(e) Date May 6, 1999 PCT Filed Nov. 5, 1997 PCT Pub. No. WO98/22425 PCT Pub. Date May 28, 1998The present invention relates to a process for preparing cyclopropylamines of the formula wherein R1, R2, R3, R4, and R5 have specified meanings, by reacting (1) a carboxamide of the formula wherein R1, R2, and R3 have specified meanings, with (2) an olefin of the formula wherein R4, R5, and R6 have specified meanings, (3) alkylmagnesium halides or zinc alkyl compounds of the formulaR8-X(VIII),wherein R8 has a specified meaning and X represents MgCl, MgBr, Mgl, ZnCl, ZnBr, Znl, or ZnR8, and (4) orthometallates of the formula (IX) wherein R9 has a specified meaning, Y represents Ti, Zr, or V=O, and Z represents chlorine, bromine, or C1-C4-alkyl, with the provisos that when is Y os Ti or Zr, then is 3 or 4 and r are zero or 1 and the sum q+r=4, and that when Y is V=O, then q represents 3 and r represents zero.