361990-21-8

Upstream product

• 2101-88-4 1-azido-4-bromobenzene 
• 141-97-9 ethyl acetoacetate 
• 106-40-1 4-bromo-aniline 
• 64-17-5 ethanol 
• 20725-34-2 1-(4-bromo-phenyl)-5-methyl-1H-[1,2,3]triazole-4-carboxylic acid 

Relevant academic research and scientific papers

Palladium-catalysed direct arylation of heteroarenes using 1-(bromophenyl)-1,2,3-triazoles as aryl source

A variety of 1-aryl-1,2,3-triazoles containing heteroarenes at C2-, C3- or C4-positions on the aryl ring was successfully prepared via palladium-catalysed direct arylation. These couplings were performed employing 1?mol% of phosphine-free Pd(OAc)2catalyst with 1-(bromophenyl)-1,2,3-triazoles and heteroarenes as coupling partners. A wide variety of heteroarenes such as thiazoles, thiophenes, furans, pyrroles or isoxazoles was tolerated.

Design, synthesis, and anticancer activity evaluation of novel aziridine-1,2,3-triazole hybrid derivatives

Some new 1-aryl-4-[(aziridine-1-yl)diaryl-methyl]-5-methyl-1H-1,2,3-triazole derivatives 7j–s were synthesized by the one-pot reaction of diaryl-(1-aryl-5-methyl-1H-1,2,3-triazol-4-yl)methanol compounds 6j–s formed from 1-aryl-5-methyl-1H-1,2,3-triazole-4

Design, synthesis and biological studies of some new imidazole-1,2,3-triazole hybrid derivatives

Some new 4-((1H-imidazol-1-yl)diarylmethyl)-5-methyl-1-aryl-1H-1,2,3-triazoles 7a-i were designed and synthesized by the one-pot reaction of diaryl-(1-aryl-5-methyl-1H-1,2,3-triazol-4-yl)methanol compounds with 1H-imidazole. The new compounds 7a-i were ch

An integrated high-throughput strategy enables the discovery of multifunctional ionic liquids for sustainable chemical processes

Development of new chemical processes with simplified reaction systems and work-up procedures is a challenging task. Although ionic liquids are a class of potential multifunctional compounds to simplify traditional chemical processes, their rational design is difficult due to complex interactions. In this work, a proof-of-concept strategy has been proposed to achieve an integration of high-throughput preparation of ionic liquids and in situ screening of their reaction-promoting performance in 96-well plates. The integrated approach then enables a facile identification of optimal ionic liquids from a 400-ionic liquid candidate pool to act as the solvent, the catalyst and the separating assistant, simultaneously, for carbonyl-azide cycloaddition reactions. Merits of the ionic liquids-based processes have been demonstrated not only in the convenient and efficient synthesis of 1,2,3-triazolyl compounds but also in the discovery of a new reaction for the chemical post-modification of free peptides.

Regiospecific synthesis of 1,4,5-trisubstituted 1,2,3-triazoles via enolate-azide cycloaddition between 1,3-dicarbonyl compounds and aryl azides

A cycloaddition reaction at room temperature between aryl azides and 1,3-dicarbonyl compounds in the presence of potassium carbonate in dimethylsulphoxide yielded 10 4-ethoxycarbonyl-1-aryl-5-methyl-1H-1,2,3-triazoles and seven other closely-related compounds. The 1,2,3-triazoles, nine of which are new, were obtained in good to high yields and only the 1,4-regioisomers were formed.

CuCO3-CuO nanocomposite as a novel and environmentally friendly catalyst for triazole synthesis

This paper focuses on the use of natural sources for the preparation of efficient and low cost catalysts. CaCO3 is obtained from cuttlefish bone and was modified by the cation exchange of Ca2+ by Cu2+ in CaCO3 u

Synthesis of biologically as well as industrially important 1,4,5-trisubstituted-1,2,3-triazoles using a highly efficient, green and recyclable DBU-H2O catalytic system

Substituted 1,2,3-triazoles are important heterocyclic molecules with applications in diverse research areas. 1,3-Dipolar cycloaddition reaction of azides and enolizable compounds is an important method of generating substituted 1,2,3-triazoles. However,

Efficient, green and regioselective synthesis of 1,4,5-trisubstituted-1,2, 3-triazoles in ionic liquid [bmim]BF4 and in task-specific basic ionic liquid [bmim]OH

Convenient and environmentally benign procedures have been reported for the synthesis of 1,4,5-trisubstituted-1,2,3-triazoles by the reaction of aryl azides with active methylene compounds in ionic liquid [bmim]BF4 in the presence of l-proline

1H and 13C NMR - Spectroscopy of substituted 1,2,3-triazoles

1-Aryl-4-carboxy-5-methyl-1,2,3-triazoles were prepared by the condensation of aryl azides with ethyl acetoacetate. The structures of these compounds were characterized by MS, IR and 1H and 13C NMR spectroscopy. The measured and calc