Butanoic acid, 2-phenylhydrazide

Base Information

• Chemical Name: Butanoic acid, 2-phenylhydrazide
• CAS No.: 20730-03-4
• Molecular Formula: C10H14N2O
• Molecular Weight: 178.234
• Mol file: 20730-03-4.mol

Synonyms:N′-phenylbutanehydrazide;β-Butyryl-phenylhydrazin;butyric acid-(N'-phenyl-hydrazide);Buttersaeure-(N'-phenyl-hydrazid);Butyric acid N'-phenyl-hydrazide;N'-Butyryl-N-phenyl-hydrazin;N-Phenyl-N'-butyryl-hydrazin;

Chemical Property of Butanoic acid, 2-phenylhydrazide

Chemical Property:

• PSA: 41.13000
• LogP: 2.39370

Purity/Quality:

99% ^*data from raw suppliers

N'-PHENYLBUTANEHYDRAZIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Butanoic acid, 2-phenylhydrazide

There total 9 articles about Butanoic acid, 2-phenylhydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

phenylhydrazine (100-63-0) + butyric acid (107-92-6) → butyric acid N'-phenyl-hydrazide (20730-03-4)

Guidance literature:

at 80 ℃; for 1.5h;

DOI:10.1139/v98-125

Reference yield:

β-butyryloxy-crotonic acid methyl ester + phenylhydrazine (100-63-0) → edaravone (89-25-8) + butyric acid N'-phenyl-hydrazide (20730-03-4)

Guidance literature:

Reference yield:

butyryl chloride (141-75-3) + phenylhydrazine (100-63-0) → butyric acid N'-phenyl-hydrazide (20730-03-4)

Guidance literature:

With pyridine; Inert atmosphere;

DOI:10.1021/acs.orglett.7b01961

upstream raw materials:

butanoic acid anhydride

phenylhydrazine

1,1-dichlorobutane

acetic butyric anhydride

Downstream raw materials:

5-oxo-1-phenyl-3-propyl-1,5-dihydro-[1,2,4]triazole-4-carboxylic acid amide

3-ethyloxindole

N-butyl-N'-phenylhydrazine

C₁₂H₁₄N₂O₂

Refernces

• 1、 Yavari, Issa,Khaledian, Omid. "A formal [3+2] cycloaddition reaction of: N -methylimidazole as a masked hydrogen cyanide: Access to 1,3-disubstitued-1 H -1,2,4-triazoles". supporting information. p. 9150 - 9153. Retrieved 2020/10/02.
• 2、 Verardo, Giancarlo,Toniutti, Nicoletta,Giumanini, Angelo G.. "Preparation, properties, and reductive alkylation of arylhydrazides". . p. 1180 - 1187. Retrieved 2007/10/03.