2075-55-0Relevant academic research and scientific papers
Real-time colorimetric screening of endopeptidase inhibitors using adenosine triphosphate (ATP)-stabilized gold nanoparticles
Kim, Mi Hee,Lee, Soo Suk,Chung, Sang J.,Jang, Hyun Hye,Yi, Sujung,Kim, Sudeok,Chang, Suk-Kyu,Han, Min Su
, p. 2228 - 2231 (2010)
The gold nanoparticles (AuNPs) that were stabilized with adenosine triphosphate (ATP) were stable over a wide range of pHs for the buffer, even in the presence of high concentrations of salt and protein. However, these stabilized AuNPs immediately aggrega
Decarbonylative approach to the synthesis of enamides from amino acids: Stereoselective synthesis of the (Z)-aminovinyl-d-cysteine unit of mersacidin
Garcia-Reynaga, Pablo,Carrillo, Angela K.,Vannieuwenhze, Michael S.
supporting information; experimental part, p. 1030 - 1033 (2012/04/04)
The Pd- and Ni-promoted decarbonylation of amino acid thioesters proceeds smoothly to yield enamides. The synthesis of the (S)-(Z)-AviMeCys subunit of mersacidin, an MRSA-active lantibiotic, via this approach, is described.
Ambient temperature synthesis of high enantiopurity N-protected peptidyl ketones by peptidyl thiol ester-boronic acid cross-coupling
Yang, Hao,Li, Hao,Wittenberg, Ruediger,Egi, Masahiro,Huang, Wenwei,Liebeskind, Lanny S.
, p. 1132 - 1140 (2007/10/03)
α-Amino acid thiol esters derived from N-protected mono-, di-, and tripeptides couple with aryl, π-electron-rich heteroaryl, or alkenyl boronic acids in the presence of stoichiometric Cu(I) thiophene-2-carboxylate and catalytic Pd2(dba)3/triethylphosphite to generate the corresponding N-protected peptidyl ketones in good-to-excellent yields and in high enantiopurity. Triethylphosphite plays a key role as a supporting ligand by mitigating an undesired palladium-catalyzed decarbonylation-β-elimination of the α-amino thiol esters. The peptidyl ketone synthesis proceeds at room temperature under nonbasic conditions and demonstrates a high tolerance to functionality.
A new convenient preparation of thiol esters utilizing N-acylbenzotriazoles
Katritzky, Alan R.,Shestopalov, Aleksandr A.,Suzuki, Kazuyuki
, p. 1806 - 1813 (2007/10/03)
Diverse thiol esters were synthesized in good to excellent yields (76-99%) by reactions of thiophenol, benzyl mercaptan, ethyl mercaptoacetate, and mercaptoacetic acid with N-acylbenzotriazoles under mild conditions. These results demonstrate the utility of N-acylbenzotriazoles as mild S-acylating agents, especially when the corresponding acid chlorides are not readily available.
Fluorometric Assay Protocol for Protease-Catalyzed Transesterification Reactions in Organic Solvents
Han, Min Su,Jung, Sang Oh,Kim, Mahn-Joo,Kim, Dong H.
, p. 2853 - 2855 (2007/10/03)
A flourometric assay protocol for a subtilisin-catalyzed transesterification reaction in n-hexane has been developed. The method makes use of a Michael acceptor that forms a fluorescent adduct with thiophenol, one of the products generated in the transest
