207598-56-9Relevant academic research and scientific papers
Stereoselective synthesis of dithymidine phosphorothioates using xylose derivatives as chiral auxiliaries
Jin, Yi,Just, George
, p. 3647 - 3654 (1998)
1,2-O-Cyclopentylidene-5-deoxy-5-isopropylamino-α-D-xylofuranose 1 and its enantiomer 11 were used as chiral auxiliaries to form, respectively, Sp and Rp dithymidine phosphorothioates 9 and 10 in 98% diastereomeric excess, using phosphoramidite methodology and 2-bromo-4,5-dicyanoimidazole as catalyst. The stereochemistry of the coupling reaction is discussed.
