207604-66-8

Upstream product

• 1041611-86-2 ethyl [4-(t-butoxycarbonylamino-methyl)-phenoxy]-acetate 
• 767-00-0 4-cyanophenol 
• 30041-95-3 ethyl (4-cyano-phenoxy)-acetate 
• 149505-94-2 tert-butyl (4-hydroxybenzyl)carbamate 

Downstream Products

• 1290056-31-3 ethyl 2-(4-((4-(((tert-butoxycarbonyl)amino)methyl)benzamido) methyl)phenoxy)acetate 
• 1290056-32-4 2-(4-((4-((Tert-butoxycarbonylamino)methyl)benzamido) methyl)phenoxy)acetic acid 
• 1290056-35-7 tert-butyl 4-(4-(2-((3R,4R)-3-(tert-butyldimethylsilyloxy)-4-hydroxypyrrolidin-1-yl)-2-oxoethoxy)benzylcarbamoyl)benzylcarbamate 
• 1290056-33-5 tert-butyl 4-(4-(2-((3s,4s)-3-(tert-butyldimethylsilyloxy)-4-hydroxypyrrolidin-1-yl)-2-oxoethoxy)benzylcarbamoyl)benzylcarbamate 
• 1290056-36-8 (R)-tert-butyl 4-(4-(2-(3-(tert-butyldimethylsilyloxy)-4-oxopyrrolidin-1-yl)-2-oxoethoxy)benzylcarbamoyl)benzylcarbamate 
• 1290053-53-0 (R)-4-(aminomethyl)-N-(4-(2-(3-hydroxy-4-oxopyrrolidin-1-yl)-2-oxoethoxy)benzyl)benzamide 
• 1290056-29-9 ethyl 2-(4-((4-(aminomethyl)benzamido)methyl)phenoxy)acetate 
• 1290056-88-0 4-cyano-N-(4-(2-(2,2-dimethyldihydro-3aH-[1,3]dioxolo[4,5-c]pyrrol-5(4H)-yl)-2-oxoethoxy)benzyl)benzamide 
• 1290053-54-1 4-(aminomethyl)-N-(4-(2-((3R,4R)-3,4-dihydroxypyrrolidin-1-yl)-2-oxoethoxy)benzyl)benzamide hydrochloride 
• 1290056-34-6 (S)-tert-butyl 4-(4-(2-(3-(tert-butyldimethylsilyloxy)-4-oxopyrrolidin-1-yl)-2-oxoethoxy)benzylcarbamoyl)benzylcarbamate 
• 1290056-89-1 4-(aminomethyl)-N-(4-(2-((3aR,6aS)-2,2-dimethyldihydro-3aH-[1,3]dioxolo[4,5-c]pyrrol-5(4H)-yl)-2-oxoethoxy)benzyl)benzamide 
• 1290053-51-8 (S)-4-(aminomethyl)-N-(4-(2-(3-hydroxy-4-oxopyrrolidin-1-yl)-2-oxoethoxy)benzyl)benzamide 
• 1290056-30-2 2-(4-((4-Cyanobenzamido) methyl)phenoxy)acetic acid 
• 1290056-28-8 ethyl 2-(4-((4-cyanobenzamido)methyl)phenoxy)acetate 

Relevant academic research and scientific papers

COFERONS AND METHODS OF MAKING AND USING THEM

The present invention is directed to a monomer useful in preparing therapeutic compounds. The monomer includes one or more pharmacophores which potentially binds to a target molecule with a dissociation constant of less than 300 μM and a linker element connected to the pharmacophore. The linker element has a molecular weight less than 500 daltons, is connected, directly or indirectly through a connector, to the pharmacophore.

Discovering Novel α-aminoacyl-Containing Proline Derivatives with Potent and Selective Inhibitory Activity Against Dipeptidyl Peptidase IV: Design, Synthesis, Biological Evaluation, and Molecular Modeling

On the basis of the enzyme-binding features of known potent inhibitors of dipeptidyl peptidase IV, novel α-aminoacyl-containing proline analogs (8Aa-8Ak, 8Ba-8Bj, 8Ca-8Ck, and 8Da-8Di) with the S configuration were designed, synthesized, and their activit