1041611-86-2

Upstream product

• 105-36-2 ethyl bromoacetate 
• 149505-94-2 tert-butyl (4-hydroxybenzyl)carbamate 

Downstream Products

• 1421688-72-3 ethyl 2-(4-(((S)-1-((S)-2-amino-3-(3-cyanophenyl)propanoyl)pyrrolidine-2-carboxamido)methyl)phenoxy)acetate 
• 1421688-71-2 ethyl 2-(4-(((S)-1-((S)-2-amino-3-(2-fluorophenyl)propanoyl)pyrrolidine-2-carboxamido)methyl)phenoxy)acetate 
• 1421688-70-1 ethyl 2-(4-(((S)-1-((S)-2-amino-3-(2-(trfluoromethyl)phenyl)propanoyl)pyrrolidine-2-carboxamido)methyl)phenoxy)acetate 
• 1421688-69-8 ethyl 2-(4-(((S)-1-((S)-2-amino-3-(2-cyanophenyl)propanoyl)pyrrolidine-2-carboxamido)methyl)phenoxy)acetate 
• 1421688-67-6 ethyl 2-(4-(((S)-1-((S)-2-amino-3-(4-(trfluoromethyl)phenyl)propanoyl)pyrrolidine-2-carboxamido)methyl)phenoxy)acetate 
• 1421688-65-4 ethyl 2-(4-(((S)-1-((S)-2-amino-3-(biphenyl-4-yl)propanoyl)pyrrolidine-2-carboxamido)methyl)phenoxy)acetate 
• 1421688-64-3 ethyl 2-(4-((S)-1-((S)-2-amino-3-(4-methoxyphenyl)pyrrolidine-2-carboxamido)methyl)phenoxy)acetate 
• 1421688-63-2 ethyl 2-(4-(((S)-1-((S)-2-amino-3-p-tolylpropanoyl)pyrrolidine-2-carboxamido)methyl)phenoxy)acetate 
• 1421688-62-1 ethyl 2-(4-(((S)-1-((S)-2-amino(4-?uorophenyl)propanoyl)pyrrolidine-2-carboxamido)methyl)phenoxy)acetate 
• 1421689-04-4 (S)-ethyl 2-(4-((pyrrolidine-2-carboxamido)methyl)phenoxy)acetate 
• 207604-66-8 ethyl 2-(4-(amino-methyl)phenoxy)acetate 

Relevant academic research and scientific papers

Discovering Novel α-aminoacyl-Containing Proline Derivatives with Potent and Selective Inhibitory Activity Against Dipeptidyl Peptidase IV: Design, Synthesis, Biological Evaluation, and Molecular Modeling

On the basis of the enzyme-binding features of known potent inhibitors of dipeptidyl peptidase IV, novel α-aminoacyl-containing proline analogs (8Aa-8Ak, 8Ba-8Bj, 8Ca-8Ck, and 8Da-8Di) with the S configuration were designed, synthesized, and their activit

THIAZOLIDINE DERIVATIVES AND METHODS FOR THE PREPARATION THEREOF

The present invention relates to novel 2-carbonyl-3-acyl-1,3-thiazolidines having a β-amino group on the acyl chain, in free, prodrug form or pharmaceutically acceptable salt thereof, including their enantiomers, diastereomers and racemates, as efficient inhibitors against DPP-IV. The invention further relates to the pharmaceutical compositions comprising the disclosed compounds. The present invention also relates to methods for preparing the disclosed compounds and for treating DPP-IV-mediated diseases.