1258440-72-0

Upstream product

• 1258440-55-9 5-(5-amino-1,3,4-thiadiazol-2-yl)-2-[(1-methylethyl)oxy]benzonitrile 
• 1258440-84-4 2-[(1-methylethyl)oxy]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile 
• 1258440-83-3 5-iodo-2-isopropoxy-benzonitrile 
• 1165923-89-6 1,1-dimethylethyl 6-hydroxy-5-methyl-3,4-dihydro-2(1H)-isoquinolinecarboxylate 
• 685103-95-1 2-hydroxy-5-iodobenzonitrile 
• 207691-65-4 N-tert-butoxycarbonyl-4-(tetrahydropyrrole-1-yl)-1,2,3,6-tetrahydropyridine 
• 258273-31-3 3-cyano-4-isopropoxybenzoic acid 
• 611-20-1 salicylonitrile 
• 1258440-71-9 tert-butyl 5-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 1165923-91-0 1,1-dimethylethyl 5-methyl-6-{[(trifluoromethyl)sulfonyl]oxy}-3,4-dihydro-2(1H)-isoquinolinecarboxylate 

Downstream Products

• 1258440-13-9 2-[(1-methylethyl)oxy]-5-[5-(5-methyl-1,2,3,4-tetrahydro-6-isoquinolinyl)-1,3,4-thiadiazol-2-yl]benzonitrile monohydrochloride 
• 1258440-14-0 3-[6-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-5-methyl-3,4-dihydro-2(1H)-isoquinolinyl]propanoic acid sodium salt 
• 1258440-16-2 4-[6-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-5-methyl-3,4-dihydro-2(1H)-isoquinolinyl]butanoic acid sodium salt 
• 1258440-73-1 ethyl 3-[6-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-5-methyl-3,4-dihydro-2(1H)-isoquinolinyl]propanoate 
• 1258440-74-2 ethyl 4-[6-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-5-methyl-3,4-dihydro-2(1H)-isoquinolinyl]butanoate 
• 1258856-61-9 5-(5-(2-(2,2-dimethyl-1,3-dioxan-5-yl)-5-methyl-1,2,3,4-tetrahydroisoquinolin-6-yl)-1,3,4-thiadiazol-2-yl)-2-isopropoxybenzonitrile 
• 1258852-10-6 3-[6-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-5-methyl-3,4-dihydro-2(1H)-isoquinolinyl]propanamide 
• 1258852-11-7 3-[6-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-5-methyl-3,4-dihydro-2(1H)-isoquinolinyl]-N-methylpropanamide 
• 1258852-12-8 3-[6-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-5-methyl-3,4-dihydro-2(1H)-isoquinolinyl]-N,N-dimethylpropanamide 
• 1258852-14-0 4-[6-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-5-methyl-3,4-dihydro-2(1H)-isoquinolinyl]-N-methylbutanamide 
• 1258854-13-5 5-(5-(2-(1,3-dihydroxypropan-2-yl)-5-methyl-1,2,3,4-tetrahydroisoquinolin-6-yl)-1,3,4-thiadiazol-2-yl)-2-isopropoxybenzonitrile hydrochloride 
• 1258852-18-4 5-{5-[2-(2,3-dihydroxypropyl)-5-methyl-1,2,3,4-tetrahydro-6-isoquinolinyl]-1,3,4-thiadiazol-2-yl}-2-[(1-methylethyl)oxy]benzonitrile 
• 1258852-17-3 2-[(1-methylethyl)oxy]-5-(5-{5-methyl-2-[2-(methyl oxy)ethyl]-1,2,3,4-tetrahydro-6-isoquinolinyl}-1,3,4-thiadiazol-2-yl)benzonitrile monohydrochloride 
• 1258852-16-2 5-{5-[2-(3-hydroxypropyl)-5-methyl-1,2,3,4-tetrahydro-6-isoquinolinyl]-1,3,4-thiadiazol-2-yl}-2-[(1-methylethyl)oxy]benzonitrile 

Relevant academic research and scientific papers

Navigating CYP1A Induction and Arylhydrocarbon Receptor Agonism in Drug Discovery. A Case History with S1P1 Agonists

This article describes the finding of substantial upregulation of mRNA and enzymes of the cytochrome P450 1A family during a lead optimization campaign for small molecule S1P1 agonists. Fold changes in mRNA up to 10 000-fold for CYP1A1 in vivo

S1P1 AGONISTS COMPRISING A BICYCLIC N-CONTAINING RING

The present invention relates to novel compounds of formula (I) having S1P1 agonist activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.

THIAZOLE OR THIADIZALOE DERIVATIVES FOR USE AS SPHINGOSINE 1-PHOSPHATE 1 (S1P1) RECEPTOR AGONISTS

Thiazole or thiadizaloe derivatives of formula (I) or pharmaceutical salts thereof having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their uses in the treatment of various disorders mediated