2078-19-5

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 611-71-2 MANDELIC ACID 
• 999-97-3 1,1,1,3,3,3-hexamethyl-disilazane 
• 25561-30-2 N,O-Bis(trimethylsilyl)trifluoroacetamide 

Downstream Products

• 6454-27-9 2-methyl-5-phenyl-[1,3]dioxolan-4-one 
• 343953-13-9 2-Methoxy-2-oxo-5-phenyl-2λ⁵-[1,3,2]dioxaphospholan-4-one 
• 666835-66-1 Cis-(2S,5S)-2-(tert-butyl)-5-phenyl-1,3-dioxolan-4-one 
• 81036-97-7 trans-2-tert-butyl-5-phenyl-1,3-dioxolan-4-one 
• 81036-97-7 cis-2-tert-butyl-5-phenyl-1,3-dioxolan-4-one 

Relevant academic research and scientific papers

Synthesis of trimethylsilyl carboxylates by HMDS under solvent-free conditions

A broad set of structurally different carboxylic acids were transformed into their trimethylsilyl esters with HMDS in a practically completely solvent-free process, while a catalytic amount of iodine was required in some cases. The process has several advantages over the known methods: untreated reactants, air atmosphere, mild and neutral conditions, no evolution of hydrogen halide, no need of an additional base, low amount of waste, completely without chromatography, low consumption of energy, and operational simplicity.

Partition coefficients of ketones, phenols, aliphatic and aromatic acids, and esters in n-hexane/nitromethane

Liquid-liquid partition is used in sample preparation and in countercurrent and liquid-liquid chromatographic separations. Partition coefficients are widely used in toxicology, environmental, and analytical chemistry. The K hn determination procedure for the n-hexane/ nitromethane system was optimized and partition coefficients for 99 ketones, esters and trimethylsilyl derivatives of phenols, aliphatic and aromatic acids were determined. For 130 compounds, Khn values were predicted using mathematical relationships between Khn and other physicochemical and structural parameters. Versita Sp. z o.o.