2079-49-4

Usage

Chemical class

Aromatic ketones

Structure

Contains a benzene ring with a phenyl group attached to a ketone group and an ethoxy group

Functional groups

Ketone, ethoxy, and dimethylamino groups

Dimethylamino group

Makes it a tertiary amine

Synonyms

4'-dimethylamino-2'-hydroxyacetophenone

Applications

Used as a building block in the synthesis of various heterocyclic compounds and pharmaceuticals

Biological activities

Studied for potential antimicrobial and antitumor properties

Research interest

Both academic and industrial due to versatile applications in organic synthesis and potential biological activities

Upstream product

• 107-99-3 2-(dimethylamino)ethyl chloride 
• 55368-24-6 1-(4-(2-bromoethoxy)phenyl)ethan-1-one 
• 124-40-3 dimethyl amine 
• 4584-46-7 (2-chloroethyl)dimethylamine hydrochloride 
• 99-93-4 4-Hydroxyacetophenone 

Downstream Products

• 3704-50-5 1-(4-Chlor-phenyl)-2-[4-(2-dimethylamino-ethoxy)-phenyl]-propan-2-ol 
• 1338349-92-0 1-(4-(2-(dimethylamino)ethoxy)phenyl)-3-phenyl-3-(phenylthio)propan-1-one 
• 1338349-93-1 1-(4-(2-(dimethylamino)ethoxy)phenyl)-3-phenyl-3-(p-tolylthio)propan-1-one 
• 1389310-71-7 3-fluoro-4'-(2-(dimethylamino)ethoxy)chalcone 
• 1389310-64-8 1-(4-(2-(dimethylamino)ethoxy)phenyl)-3-(4-(dimethylamino)phenyl)prop-2-en-1-one 
• 1389310-70-6 4-cyano-4'-(2-(dimethylamino)ethoxy)chalcone 
• 1389310-62-6 2-fluoro-4'-(2-(dimethylamino)ethoxy)chalcone 
• 1389310-73-9 4-fluoro-4'-(2-(dimethylamino)ethoxy)chalcone 
• 1246848-11-2 2-bromo-4'-[2-(dimethylamino)ethoxy]-acetophenone 

Relevant academic research and scientific papers

Synthesis, characterization and antiamoebic activity of chalcones bearing N -substituted ethanamine tail

A series of chalcones (4-21) possessing N-substituted ethanamine were synthesized by the aldol condensation reaction of 1-(4-(2-substituted ethoxy)phenyl)ethanones with different aldehydes preceded by the reaction of 2-chloro N-substituted ethanamine hydr

Design and synthesis of 1,3-biarylsulfanyl derivatives as new anti-breast cancer agents

A new series of 1,3-biarylsulfanyl derivatives (homodibenzyl core motif) have been designed and synthesized as new estrogen receptor ligands by chopping benzothiophene core of raloxifene to engender seco-raloxifene scaffold. All the synthesized compounds were screened for anti-proliferative, anti-osteoporotic, and anti-implantation activity. Compounds (35, 36) having basic amino anti-estrogenic side chain were exhibiting potential anti-proliferative activity in MCF-7, MDA-MB-231 and ishikawa cell lines. Some of the synthesized compounds having homodibenzyl motif (5, 8, 10) have shown moderate anti-osteoporotic activity.

Substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carbonitriles and substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carboxamides as tubulin polymerization inhibitors

Substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carbonitriles and substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carboxamides and their salts are tubulin polymerization inhibitors, useful in the treatment of cancer.

2-Amido-thiazole-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof

2-Amido-4-substituted-aryl-thiazole-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, methods of using compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions comprising compounds exhibiting ATP-utilizing enzyme

6-Aryl-4-methylsulfanyl-2H-pyran-2-one-3-carbonitriles as PPAR-γ activators

Various 6-aryl-3-cyano/methoxycarbonyl-4-methylsulfanyl-2H-pyran-2-ones have been synthesized as a potential substitute of 2,4-thiazolidinedione head group to express potent PPAR-γ transactivation response. Some of the screened compounds have shown promis

Chemotherapeutic nitroheterocycles. 18. 2 (5 Nitro 2 imidazolylmethylene) 1 indanones, 1 tetralones, and acetophenones substituted by aminoalkoxy groups

2 (5 Nitro 2 imidazolylmethylene) 1 indanones; 1 tetralones, and acetophenones with aminoalkoxy substituents, groups and related compounds, were synthesized and their antimicrobial activities were evaluated. Some of these compounds surprisingly exhibited a broad antibacterial spectrum including Proteus species and Pseudomonas aeruginosa. High antitrichomonal activities were also observed in vitro minimum inhibitory concentration of 0.0004 μg/ml) and six compounds displayed in vivo activity against Trichomonas vaginalis in mice comparable to that of metronidazole.