20803-96-7

Basic information

• Product Name: 2-(phenylsulfonyl)propanoic acid
• CAS NO: 20803-96-7
• Molecular Formula: C₉H₁₀O₄S
• Molecular Weight: 214.2383
• Mol File: 20803-96-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 442.7°C at 760 mmHg
• Flash Point: 221.5°C
• Density: 1.345g/cm³
• Vapor Pressure: 1.29E-08mmHg at 25°C
• Refractive Index: 1.554
• CAS DataBase Reference: 2-(phenylsulfonyl)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(phenylsulfonyl)propanoic acid(20803-96-7)
• EPA Substance Registry System: 2-(phenylsulfonyl)propanoic acid(20803-96-7)

Safety Data

• Hazardous Substances Data: 20803-96-7(Hazardous Substances Data)

Usage

General Description

2-(phenylsulfonyl)propanoic acid, also known as fenoprofen, is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing the levels of prostaglandins, which are chemicals that cause pain, inflammation, and fever in the body. It is commonly used to treat pain and inflammation associated with conditions such as osteoarthritis and rheumatoid arthritis. Fenoprofen is also sometimes prescribed to relieve menstrual cramps and other types of mild to moderate pain. However, it carries a risk of stomach ulcers, bleeding, and kidney damage, and should be used with caution, especially in elderly patients.

Upstream product

• 17431-94-6 2-phenylsulfanyl-propionic acid 
• 873-55-2 sodium benzenesulfonate 
• 535-11-5 Ethyl 2-bromopropionate 
• 930-69-8 sodium thiophenolate 
• 108-98-5 thiophenol 
• 146300-52-9 (R)-α-(phenylthio)propanoic acid 
• 20810-30-4 (+)(R)-2-benzenesulfinyl-propionic acid 

Downstream Products

• 38009-93-7 α-bromoethyl phenyl sulfone 
• 161180-91-2 1-methylsulfanyl-1-phenylsulfonylethane 
• 124-38-9 carbon dioxide 
• 599-70-2 ethyl phenyl sulfone 

Relevant articles and documents

Ni/Ir-Catalyzed Photoredox Decarboxylative Coupling of S-Substituted Thiolactic Acids with Heteroaryl Bromides: Short Synthesis of Sulfoxaflor and Its SF5 Analog

Metallaphotoredox cross-coupling reactions have recently emerged as a powerful tool for the construction of C(sp2)?C(sp3) bonds between alkyl chains and aromatic systems, including electron-deficient heteroaryls, which are known to be challenging coupling partners. In this article, we disclose the Ni/Ir-catalyzed photoredox decarboxylative coupling of readily available S-substituted thiolactic acids with electron-deficient heteroaryl bromides, which resulted in the formation of simple but otherwise not easily accessible heteroarenes with alkylsulfide side chains. To demonstrate a practical use of this coupling reaction, we have shown its efficiency in the one-step synthesis of a key intermediate in the synthesis of the recently marketed insecticide Sulfoxaflor, and for the short synthesis of SF5-Sulfoxaflor.

SYNTHESIS OF 2-ARYLSULFONYLISOVALERIC ACIDS

Following the rules of a systematic QSAR study aimed at designing new, more potent sweeteners, the synthesis of 2-arylsulfonylisovaleric acids was carried out.