128720-50-3Relevant academic research and scientific papers
Mapping the substrate scope of monoamine oxidase (MAO-N) as a synthetic tool for the enantioselective synthesis of chiral amines
Herter, Susanne,Medina, Florian,Wagschal, Simon,Benha?m, Cyril,Leipold, Friedemann,Turner, Nicholas J.
, p. 1338 - 1346 (2017/10/06)
A library of 132 racemic chiral amines (α-substituted methylbenzylamines, benzhydrylamines, 1,2,3,4-tetrahydronaphthylamines (THNs), indanylamines, allylic and homoallylic amines, propargyl amines) was screened against the most versatile monoamine oxidase (MAO-N) variants D5, D9 and D11. MAO-N D9 exhibited the highest activity for most substrates and was applied to the deracemisation of a comprehensive set of selected primary amines. In all cases, excellent enantioselectivity was achieved (e.e. >99%) with moderate to good yields (55–80%). Conditions for the deracemisation of primary amines using a MAO-N/borane system were further optimised using THN as a template addressing substrate load, nature of the enzyme preparation, buffer systems, borane sources, and organic co-solvents.
Catalytic Asymmetric Reductive Condensation of N–H Imines: Synthesis of C2-Symmetric Secondary Amines
Wakchaure, Vijay N.,List, Benjamin
supporting information, p. 15775 - 15778 (2016/12/16)
A highly diastereoselective and enantioselective Br?nsted acid catalyzed reductive condensation of N?H imines was developed. This reaction is catalyzed by a chiral disulfonimide (DSI), uses Hantzsch esters as a hydrogen source, and delivers useful C2-symmetric secondary amines.
CATALYTIC PREPARATION OF ENAMIDES FROM ALKYL AZIDES AND ACYL DONORS
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Paragraph 0082-0083, (2016/10/10)
The present invention relates to a method to synthesize an enamide compound by generating imine which does not have a substituent group bonded to the nitrogen from an organic azide compound and conducting a reaction of the same with acyl doner. By using t
Exploiting the Nucleophilicity of N-H Imines: Synthesis of Enamides from Alkyl Azides and Acid Anhydrides
Han, Junghoon,Jeon, Mina,Pak, Han Kyu,Rhee, Young Ho,Park, Jaiwook
, p. 2769 - 2774 (2016/02/18)
The nucleophilicity of N-unsubstituted imines, which were generated from alkyl azides by a ruthenium-catalyzed reaction, was investigated in the reaction with acid anhydrides. The initial products were N-acylimines, which isomerized to the corresponding e
Synthesis of aryl ketones via decarboxylation of aromatic acids under solvothermal condition
Rai, K.M. Lokanatha,Babu, M. Suresh,Byrappa
experimental part, p. 1395 - 1396 (2012/08/27)
Aryl ketones were prepared by the condensation of aromatic carboxylic acids with alkyl/aryl nitrile via the decarboxylation of carboxylic acids under solvothermal condition. All the compounds were characterized by comparing with standard samples prepared by the known literature method.
Ruthenium Complex Catalyzed Selective Deoxygenation of Ketoximes to Ketimines
Akazome, Motohiro,Tsuji, Yasushi,Watanabe, Yoshihisa
, p. 635 - 638 (2007/10/02)
Ru3(CO)12 showed high catalytic activity for the deoxygenation of various ketoximes to the corresponding ketimines under carbon monoxide pressure (20 kg/cm2).For the deoxygenation of propiophenone oxime, ethyl phenyl ketimine was obtained in 100 percent yield.On the other hand, heptanal oxime which was aldoxime was dehydrated under the same conditions to the corresponding nitrile in 32 percent yield.
