2084-72-2

Basic information

• Product Name: N-2,3-DIHYDRO-1H-INDEN-1-YL-N-METHYLAMINE
• Synonyms: N-2,3-DIHYDRO-1H-INDEN-1-YL-N-METHYLAMINE;Indan-1-yl-Methyl-aMine
• CAS NO: 2084-72-2
• Molecular Formula: C₁₀H₁₃N
• Molecular Weight: 147.22
• Mol File: 2084-72-2.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-2,3-DIHYDRO-1H-INDEN-1-YL-N-METHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-2,3-DIHYDRO-1H-INDEN-1-YL-N-METHYLAMINE(2084-72-2)
• EPA Substance Registry System: N-2,3-DIHYDRO-1H-INDEN-1-YL-N-METHYLAMINE(2084-72-2)

Safety Data

• Hazardous Substances Data: 2084-72-2(Hazardous Substances Data)

Usage

General Description

N-2,3-dihydro-1H-inden-1-yl-N-methylamine is a chemical compound with the molecular formula C11H15N. It is a derivative of indene, which is a bicyclic aromatic hydrocarbon. N-2,3-DIHYDRO-1H-INDEN-1-YL-N-METHYLAMINE is an amine, with a methyl group attached to the nitrogen atom and an indenyl group attached to the amine. It is a colorless liquid with a molecular weight of 161.24 g/mol. N-2,3-DIHYDRO-1H-INDEN-1-YL-N-METHYLAMINE has potential applications in organic synthesis and pharmaceutical research due to its unique structure and functional groups, but it may also have potential hazards and safety considerations due to its chemical properties.

Upstream product

• 83-33-0 inden-1-one 
• 74-89-5 methylamine 
• 124369-50-2 1,1-Dimethyl-2,3-epoxy-5-nitro-indane 
• 34698-41-4 2,3-dihydro-1H-inden-1-amine 
• 14381-42-1 Indan-1-carboxylic acid 
• 31502-89-3 N-indan-1-ylformamide 
• 35275-62-8 1-chloroindane 

Downstream Products

• 83-33-0 inden-1-one 
• 10277-78-8 N-methyl-1(R)-aminoindan 
• 66512-63-8 N-methyl-1(S)-aminoindan 
• 95-13-6 1-indene 
• 861361-34-4 indan-1-yl-(2-nitro-phenyl)-amine 
• 35275-62-8 1-chloroindane 
• 6351-10-6 1-Indanol 

Relevant articles and documents

Tackling N-Alkyl Imines with 3d Metal Catalysis: Highly Enantioselective Iron-Catalyzed Synthesis of α-Chiral Amines

A readily activated iron alkyl precatalyst effectively catalyzes the highly enantioselective hydroboration of N-alkyl imines. Employing a chiral bis(oxazolinylmethylidene)isoindoline pincer ligand, the asymmetric reduction of various acyclic N-alkyl imines provided the corresponding α-chiral amines in excellent yields and with up to >99 % ee. The applicability of this base metal catalytic system was further demonstrated with the synthesis of the pharmaceuticals Fendiline and Tecalcet.

Photometric Characterization of the Reductive Amination Scope of the Imine Reductases from Streptomyces tsukubaensis and Streptomyces ipomoeae

Imine reductases (IREDs) have emerged as promising enzymes for the asymmetric synthesis of secondary and tertiary amines starting from carbonyl substrates. Screening the substrate specificity of the reductive amination reaction is usually performed by time-consuming GC analytics. We found two highly active IREDs in our enzyme collection, IR-20 from Streptomyces tsukubaensis and IR-Sip from Streptomyces ipomoeae, that allowed a comprehensive substrate screening with a photometric NADPH assay. We screened 39 carbonyl substrates combined with 17 amines as nucleophiles. Activity data from 663 combinations provided a clear picture about substrate specificity and capabilities in the reductive amination of these enzymes. Besides aliphatic aldehydes, the IREDs accepted various cyclic (C4–C8) and acyclic ketones, preferentially with methylamine. IR-Sip also accepted a range of primary and secondary amines as nucleophiles. In biocatalytic reactions, IR-Sip converted (R)-3-methylcyclohexanone with dimethylamine or pyrrolidine with high diastereoselectivity (>94–96 % de). The nucleophile acceptor spectrum depended on the carbonyl substrate employed. The conversion of well-accepted substrates could also be detected if crude lysates were employed as the enzyme source.

TACHYKININ RECEPTOR ANTAGONISTS

The present invention relates to selective NK-1 receptor antagonists of Formula (I) or a pharmaceutically acceptable salt thereof, for the treatment of disorders associated with an excess of tachykinins.