35275-62-8

Basic information

• Product Name: 1-chloroindan
• Synonyms: 1-chloroindan;4-CHLOROPHTHALONITRILE;1-Chloro-2,3-dihydro-1H-indene;α-Chlorindane;1-Chloro-2,3-dihydroindene;1-Indanyl chloride
• CAS NO: 35275-62-8
• Molecular Formula: C₉H₉Cl
• Molecular Weight: 152.62076
• EINECS: 252-480-8
• Product Categories: pharmacetical
• Mol File: 35275-62-8.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 229℃
• Flash Point: 76℃
• Appearance: /
• Density: 1.15
• Vapor Pressure: 0.11mmHg at 25°C
• Refractive Index: 1.57
• CAS DataBase Reference: 1-chloroindan(CAS DataBase Reference)
• NIST Chemistry Reference: 1-chloroindan(35275-62-8)
• EPA Substance Registry System: 1-chloroindan(35275-62-8)

Safety Data

• Hazardous Substances Data: 35275-62-8(Hazardous Substances Data)

Usage

General Description

1-Chloroindan is a chemical compound with the molecular formula C9H9Cl. It is a chlorinated derivative of indane, which is a bicyclic hydrocarbon. 1-Chloroindan is a colorless liquid at room temperature, and it is used in the production of pharmaceuticals and agrochemicals. It is also used as a building block in the synthesis of various organic compounds. 1-Chloroindan is considered to have low toxicity, but it should be handled with care as it is still a hazardous chemical. Its chemical structure and properties make it valuable in various industrial applications and research purposes.

InChI:InChI=1/C9H9Cl/c10-9-6-5-7-3-1-2-4-8(7)9/h1-4,9H,5-6H2

Upstream product

• 6351-10-6 1-Indanol 
• 7647-01-0 hydrogenchloride 
• 95-13-6 1-indene 
• 2084-72-2 N-methyl-1-indanamine 
• 83-33-0 inden-1-one 

Downstream Products

• 861361-34-4 indan-1-yl-(2-nitro-phenyl)-amine 
• 783335-07-9 indan-1-yl-o-tolyl-amine 
• 83-33-0 inden-1-one 
• 6351-10-6 1-Indanol 
• 34698-41-4 2,3-dihydro-1H-inden-1-amine 
• 95-13-6 1-indene 
• 199924-88-4 di(1-indanyl) ether 
• 1383435-89-9 benzyl 4-(2,3-dihydro-1H-inden-1-yl)benzoate 

Relevant articles and documents

Thiourea-Mediated Halogenation of Alcohols

The halogenation of alcohols under mild conditions expedited by the presence of substoichiometric amounts of thiourea additives is presented. The amount of thiourea added dictates the pathway of the reaction, which may diverge from the desired halogenation reaction toward oxidation of the alcohol, in the absence of thiourea, or toward starting material recovery when excess thiourea is used. Both bromination and chlorination were highly efficient for primary, secondary, tertiary, and benzyl alcohols and tolerate a broad range of functional groups. Detailed electron paramagnetic resonance (EPR) studies, isotopic labeling, and other control experiments suggest a radical-based mechanism. The fact that the reaction is carried out at ambient conditions, uses ubiquitous and inexpensive reagents, boasts a wide scope, and can be made highly atom economic, makes this new methodology a very appealing option for this archetypical organic reaction.

Nickel-Catalyzed Reductive Cross-Coupling of Benzyl Halides with Aryl Halides

Systematic studies of the coupling of benzylic with aryl halides are presented. The optimized reaction conditions for electron-deficient aryl halides cannot be applied to the electron-rich or neutral counterparts, and vice versa. The excellent functional group tolerance and broad substrate scope may enable the current work to be useful for the construction of diaryl methane products.

Nickel-catalyzed asymmetric reductive cross-coupling between vinyl and benzyl electrophiles

A Ni-catalyzed asymmetric reductive cross-coupling between vinyl bromides and benzyl chlorides has been developed. This method provides direct access to enantioenriched products bearing aryl-substituted tertiary allylic stereogenic centers from simple, stable starting materials. A broad substrate scope is achieved under mild reaction conditions that preclude the pregeneration of organometallic reagents and the regioselectivity issues commonly associated with asymmetric allylic arylation.