208457-45-8

Usage

Molecular weight

251.06 g/mol

Appearance

White crystalline powder

Odor

Faint

Physical state

Solid

Uses

a. Building block in the synthesis of polymers
b. Production of plastics, resins, and coatings

Polymers synthesized

a. Polyethylene terephthalate (PET)
b. Polybutylene terephthalate (PBT)

Function

Plasticizer, increasing flexibility and durability of materials

Properties

a. High performance
b. Heat resistance

Applications

a. Consumer products
b. Industrial products

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 6968-28-1 4-bromophthalic acid 
• 85-44-9 phthalic anhydride 
• 86-90-8 4-bromophthalic anhydride 

Downstream Products

• 65-85-0 benzoic acid 

Relevant academic research and scientific papers

Synthesis and biological evaluation of chemokine receptor ligands with 2-benzazepine scaffold

Targeting CCR2 and CCR5 receptors is considered as promising concept for the development of novel antiinflammatory drugs. Herein, we present the development of the first probe-dependent positive allosteric modulator (PAM) of CCR5 receptors with a 2-benzazepine scaffold. Compound 14 (2-isobutyl-N-({[N-methyl-N-(tetrahydro-2H-pyran-4-yl)amino]methyl}phenyl)-1-oxo-2,3-dihydro-1H-2-benzazepine-4-carboxamide) activates the CCR5 receptor in a CCL4-dependent manner, but does not compete with [3H]TAK-779 binding at the CCR5. Furthermore, introduction of a p-tolyl moiety at 7-position of the 2-benzazepine scaffold turns the CCR5 PAM 14 into the selective CCR2 receptor antagonist 26b. The structure affinity and activity relationships presented here offer new insights into ligand recognition by CCR2 and CCR5 receptors.

FUROISOQUINOLINE DERIVATIVE AND USE THEREOF

The present invention provides a compound represented by the formula ???wherein A represents (1) a bond, (2) a group represented by the formula -CRa=CRb- (Ra and Rb each represent a hydrogen atom or C1-6 alkyl) and the like; R1 represents (1) cyano or (2) an optionally esterified or amidated carboxyl group; R2 represents(1) a hydrogen atom, (2) an optionally substituted hydroxy group,(3) an optionally substituted amino group and the like; R3 and R4 each represent a hydrogen atom and the like; R5 represents a hydrogen atom and the like; R6 represents an optionally substituted hydroxy group and the like; R7and R8 each represent an optionally substituted hydrocarbon group and the like; R9 and R10 each represent (1) a hydrogen atom and the like; Y represents an optionally substituted methylene group; and n represents 0 or 1, or a salt thereof, which has an excellent phosphodiesterase IV inhibiting action.