208529-48-0Relevant academic research and scientific papers
The application of disubstituted vinylogous iminium salts and related synthons to the regiocontrolled preparation of unsymmetrical 2,3,4- trisubstituted pyrroles
Gupton, John T.,Krumpe, Keith E.,Burnham, Bruce S.,Dwornik, Kate A.,Petrich, Scott A.,Du, Karen X.,Bruce, Marc A.,Vu, Phong,Vargas, Marian,Keertikar, Kartik M.,Hosein, Kirsten N.,Jones, Claude R.,Sikorski, James A.
, p. 5075 - 5088 (1998)
Reactions of 2,3-disubstituted chloropropeniminium salts and related synthons with ethyl glycinate, ethyl N-methylglycinate, and ethyl N- benzylglycinate have been studied under acidic, basic and neutral conditions. Such reactions have resulted in efficient and selective methodology for the synthesis of unsymmetrical 2,3,4-trisubstituted pyrrole systems.
INHIBITORS OF METALLO-BETA-LACTAMASES
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Paragraph 00255; 00256, (2018/12/13)
The present invention relates to compounds of Formula (I) that function as inhibitors of bacterial metallo-beta-lactamases. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of a bacterial infection. (Formula (I))
1,3-Disubstituted 4-methyl-1H-pyrrole-2-carboxamides and their Use in Medicaments
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Page/Page column 32, (2009/06/27)
1,3-disubstituted 4-methyl-1H-pyrrole-2-carboxamides corresponding to formula I methods for their production, pharmaceutical compositions containing them, and the use thereof for noradrenalin receptor regulation, particularly for inhibiting noradrenalin reuptake, and/or for 5-HT receptor regulation, particularly for inhibiting 5-hydroxy tryptophan reuptake, and/or for opioid receptor regulation and/or for batrachotoxin (BTX) receptor regulation and/or for treating or inhibiting pain and other conditions.
