20876-28-2Relevant academic research and scientific papers
Non-nucleoside reverse transcriptase inhibitors
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Page 11, (2010/02/07)
Compounds represented by formula I: wherein R1 is H, halogen, (C1-4)alkyl, O(C1-4)alkyl, and haloalkyl; R2 is H or (C1-4)alkyl; R3 is H or (C1-4)alkyl; R4 is (C1-4)alkyl, (C1-4)alkyl(C3-7)cycloalkyl, or (C3-7)cycloalkyl; and Q is a fused phenyl-5 or 6-membered saturated heterocycle having one to two heteroatoms selected from O and N, said Q being optionally substituted with hydroxy, or (C1-4)alkyl which in turn maybe optionally substituted with pyridinyl-N-oxide or C(O)OR wherein R is H or (C1-4)alkyl; or a salt thereof. The compounds have inhibitory activity against Wild Type, and single and double mutants strains, of HIV.
Novel substituted 4-aminomethylpiperidines as potent and selective human β3-agonists. Part 1: Aryloxypropanolaminomethylpiperidines
Steffan, Robert J.,Ashwell, Mark A.,Solvibile, William R.,Matelan, Edward,Largis, Elwood,Han, Stella,Tillet, Jeffery,Mulvey, Ruth
, p. 2957 - 2961 (2007/10/03)
The synthesis and SAR of a series of human β3 adrenoreceptor agonists based on a template derived from a common pharmacophore coupled with 4-aminomethylpiperidine is described. Potent and selective agents were identified such as 26 that was in vitro active in CHO cells expressing human β3-AR (EC50=49 nM, IA=1.1), and in vivo active in a transgenic mouse model.
Esters and amides of substituted pyrrole acetic acids
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, (2008/06/13)
Esters and amides of substituted pyrrole acetic acids are useful in the treatment of colonic polyps.
SYNTHETIC STUDIES ON FR900482: PROMISING METHOD TO CONSTRUCT THE BICYCLIC HYDROXYLAMINE HEMI-KETAL RING SYSTEM
Yasuda, Nobuyoshi,Williams, Robert M.
, p. 3397 - 3400 (2007/10/02)
Intramolecular reductive amination is utilized as a key 8-membered ring-forming cyclization reaction to construct the novel bicyclic hydroxylamine hemi-ketal ring system of FR900482.
