7699-17-4

Usage

Uses

Used in Organic Synthesis:
4-Methoxy-2-indolinone is used as a key intermediate for the synthesis of various organic compounds, contributing to the development of new chemical entities and enhancing the diversity of chemical libraries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-Methoxy-2-indolinone is used as a building block for the synthesis of various medications, leveraging its structural features to create novel therapeutic agents with improved pharmacological properties.
Used in Dye and Pigment Preparation:
4-Methoxy-2-indolinone is utilized as a precursor in the preparation of dyes and pigments, offering a wide range of color options and enhancing the performance of these colorants in various applications.
Used in Antimicrobial Applications:
4-Methoxy-2-indolinone is used as an anti-fungal and anti-bacterial agent, thanks to its potential to inhibit the growth of various microorganisms, making it a valuable component in pharmaceutical research for developing new antimicrobial drugs.
Used in Anti-inflammatory Research:
Due to its potential anti-inflammatory properties, 4-Methoxy-2-indolinone is employed in pharmaceutical research to explore its capacity to modulate inflammatory responses, offering a promising avenue for the development of new anti-inflammatory medications.

InChI:InChI=1/C9H9NO2/c1-12-8-4-2-3-7-6(8)5-9(11)10-7/h2-4H,5H2,1H3,(H,10,11)

Upstream product

• 64208-72-6 2-chloromethyl-3-nitro-anisole 
• 20876-27-1 (6-methoxy-2-nitrophenyl)acetonitrile 
• 19689-86-2 2-nitro-6-methoxybenzyl bromide 
• 86915-04-0 7-methoxy-3-methyl-3-thiomethyl oxindole 
• 20876-28-2 2-(2-methoxy-6-nitrophenyl)acetic acid 
• 93-25-4 2-methoxyphenylacetic acid 

Downstream Products

• 7699-21-0 4-methoxy-1-methyloxindole 
• 13402-55-6 4-Hydroxy-oxindol 
• 192928-47-5 4-methoxy-3,3-dimethyl-1,3-dihydro-indol-2-one 
• 424792-50-7 4'-methoxyspiro[cyclopropane-1,3'-indol]-2'(1'H)-one 
• 424792-47-2 C₁₆H₁₅NO₂ 
• 93831-00-6 4-methoxy-2-oxoindoline-3-spirocyclopentane 
• 7556-35-6 4-methoxy-1-methyl-1H-indole 

Relevant academic research and scientific papers

A Unified Catalytic Asymmetric (4+1) and (5+1) Annulation Strategy to Access Chiral Spirooxindole-Fused Oxacycles

A unified catalytic asymmetric (N+1) (N=4, 5) annulation reaction of oxindoles with bifunctional peroxides has been achieved in the presence of a chiral phase-transfer catalyst (PTC). This general strategy utilizes peroxides as unique bielectrophilic four- or five-atom synthons to participate in the C?C and the subsequent umpolung C?O bond-forming reactions with one-carbon unit nucleophiles, thus providing a distinct method to access the valuable chiral spirooxindole-tetrahydrofurans and -tetrahydropyrans with good yields and high enantioselectivities under mild conditions. DFT calculations were performed to rationalize the origin of high enantioselectivity. The gram-scale syntheses and synthetic utility of the resultant products were also demonstrated.

Room Temperature Benzofused Lactam Synthesis Enabled by Cobalt(III)-Catalyzed C(sp2)?H Amidation

Benzofused lactams, especially indolin-2-one and dihydroquinolin-2-one are popular structural motives in durgs and natural products. Herein, we developed a room temperature and robust synthesis of benzofused lactams through cobalt(III)-catalyzed C(sp

CYCLOHEXYL AMIDE DERIVATIVES AS CRF RECEPTOR ANTAGONISTS

There are described cydohexyl amide derivatives useful as corticotropin releasing factor (CRF) receptor antagonists

Non-nucleoside reverse transcriptase inhibitors

Compounds represented by formula I: wherein R1 is H, halogen, (C1-4)alkyl, O(C1-4)alkyl, and haloalkyl; R2 is H or (C1-4)alkyl; R3 is H or (C1-4)alkyl; R4 is (C1-4)alkyl, (C1-4)alkyl(C3-7)cycloalkyl, or (C3-7)cycloalkyl; and Q is a fused phenyl-5 or 6-membered saturated heterocycle having one to two heteroatoms selected from O and N, said Q being optionally substituted with hydroxy, or (C1-4)alkyl which in turn maybe optionally substituted with pyridinyl-N-oxide or C(O)OR wherein R is H or (C1-4)alkyl; or a salt thereof. The compounds have inhibitory activity against Wild Type, and single and double mutants strains, of HIV.

Novel substituted 4-aminomethylpiperidines as potent and selective human β3-agonists. Part 1: Aryloxypropanolaminomethylpiperidines

The synthesis and SAR of a series of human β3 adrenoreceptor agonists based on a template derived from a common pharmacophore coupled with 4-aminomethylpiperidine is described. Potent and selective agents were identified such as 26 that was in vitro active in CHO cells expressing human β3-AR (EC50=49 nM, IA=1.1), and in vivo active in a transgenic mouse model.

A VERSATILE AND EFFICIENT PROCESS TO 3-SUBSTITUTED INDOLES FROM ANILINES

Borane-mediated reductive elimination of α-thiomethyl-, α-hydroxy-, or α-alkoxy-, α'-substituted oxindoles affords 3-substituted indoles in high yield.Isatins, available via several routes from oxindoles, also afford indoles.