2089-03-4

Upstream product

• 88-18-6 2-tert-Butylphenol 
• 106-95-6 allyl bromide 
• 107-18-6 allyl alcohol 
• 107-05-1 3-chloroprop-1-ene 

Downstream Products

• 1610349-83-1 (E)-2-[3-(2-tert-butylphenoxy)-1-propen-1-yl]thiophene 
• 1610349-89-7 (E)-1-[3-(2-tert-butylphenoxy)-2-propen-1-yl]naphthalene 
• 1610349-71-7 (E)-cinnamyl 2-tert-butylphenyl ether 
• 88-18-6 2-tert-Butylphenol 
• 3354-55-0 2-(1,1-dimethylethyl)-6-(2-propenyl)phenol 

Relevant academic research and scientific papers

A mild and practical method for deprotection of aryl methyl/benzyl/allyl ethers with HPPh2andtBuOK

A general method for the demethylation, debenzylation, and deallylation of aryl ethers using HPPh2andtBuOK is reported. The reaction features mild and metal-free reaction conditions, broad substrate scope, good functional group compatibility, and high chemical selectivity towards aryl ethers over aliphatic structures. Notably, this approach is competent to selectively deprotect the allyl or benzyl group, making it a general and practical method in organic synthesis.

An efficient palladium-catalyzed synthesis of cinnamyl ethers from aromatic halides, phenols, and allylic chloride

A one-pot, two-step catalytic protocol for the preparation of cinnamyl ethers from simple and readily available aryl halides, phenols and allyl chloride is reported for the first time. This simple and highly efficient palladium nanoparticles catalytic system shows good regio- and stereoselectivities and affords the desired products in good to high yields (49-85%) from aryl iodides. Furthermore, less reactive aryl bromides can also give the cinnamyl ethers in moderate yields (24-72%).

Thermodynamic, spectroscopic, and density functional theory studies of allyl aryl and prop-1-enyl aryl ethers. Part 1. Thermodynamic data of isomerization

A chemical equilibration study of the relative thermodynamic stabilities of seventy isomeric allyl aryl ethers (a) and (Z)-prop-1-enyl aryl ethers (b) in DMSO solution has been carried out. From the variation of the equilibrium constant with temperature the Gibbs energies, enthalpies, and entropies of isomerization at 298.15 K have been evaluated. Because of their low enthalpies, the (Z)-prop-1-enyl aryl ethers are strongly favored at equilibrium, the Gibbs energies of the a→b isomerization ranging from -12 to -23 kJ mol-1. The entropy contribution is negligible in most reactions, but occasionally small positive values less than +10 J K-1 mol-1 of the entropy of isomerization are found. The equilibration studies were also extended to involve two pairs of related isomeric ethers with a Me substituent on C(2) of the olefinic bond. The Me substituent was found to increase the relative thermodynamic stability of the allylic ethers by ca. 3.4 kJ mol-1.

Process for the preparation of certain substituted aromatic compounds

The present invention involves process for the preparation of compounds having the chemical structure: STR1 wherein Ar--H is an aromatic compound which is activated to an electrophilic attack, and wherein --Y is an aliphatic group having a labile moiety,

Tert-butylphenyl compounds useful as anti-inflammatory agents

The present invention involves compounds having the structure: STR1 wherein: (a) --A1 is selected from the group consisting of --OH, --H, and --O2 CR; (b) --A2 is selected from the group consisting of unsubstituted or substituted, saturated or unsaturated, straight, branched and cyclic alkyl having from 1 to about 10 carbon atoms; (c)--A3 is selected from --C(CH3)3, --Si(CH3)3, and --CF3 ; and (d) --Y is selected from certain low molecular weight alkyl chains which terminate in specific unsaturated functional groups: STR2 and aldehydes in the form of their acetals; pharmaceutical compositions comprising such compounds; and methods for treating inflammation by administering such compounds.