208983-73-7Relevant academic research and scientific papers
Antiviral agents and methods of treating viral infections
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, (2008/06/13)
The present invention relates to methods of treating viral or fungal infections using 3-aminopyridine-2-carboxyaldehyde thiosemicarbazone (3-AP) and 3-amino-4-methylpyridine-2-carboxaldehyde thiosemicarbazone (3-AMP) and its prodrug forms and to pharmaceutical compositions comprising these compounds.
Modified prodrug forms of AP/AMP
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, (2008/06/13)
The present invention relates to compounds according to the structure: Where R is H or CH3; R2 is phosphate which can be free acid or salt; R3 is H, F, Cl, Br, I, OCH3, OCF3, CF3 or a C1-C3 alkyl group; R4 is H, F, Cl, Br, I, OCH3, OCF3 or CF3; and R5 and R6 are each independently H, F, Cl, Br, I, OCH3, OCF3 or CF3, with the proviso that when any two of R3, R4, R5 or R6 are other than H, the other two of R3, R4, R5 or R6 are H which may be used to treat neoplasia, including cancer.
Synthesis and biological evaluation of a water soluble phosphate prodrug of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP)
Li, Jun,Luo, Xiang,Wang, Qin,Zheng, Li-Mou,King,Doyle, Terrence W.,Chen, Shu-Hui
, p. 3159 - 3164 (2007/10/03)
With the aim of improving its biological and pharmaceutical profiles, two water soluble phosphate prodrugs of 3-AP, 3a and 3b were prepared. The detailed synthesis and the preliminary evaluation of these prodrugs are described.
On the stille vinylation reactions with α-styryltrimethyltin
Chen, Shu-Hui
, p. 4741 - 4744 (2007/10/03)
Stille vinylation reactions involving α-styryltrimethyltin 3b and a series of chloro- or bromo-pyridine derivatives are described. In contrast to the rare cine selectivity observed with iodobenzene 10a or 3-iodotoluene 10b, reactions between vinyltin 3b and a series of 2-halopyridine derivatives 15(a-d) yield 1,1-disubstituted ipso-coupled olefins 16(a-d) as the predominant products.
