20904-57-8

Upstream product

• 588-63-6 3-phenoxypropyl bromide 
• 124-40-3 dimethyl amine 
• 109-54-6 3-(Dimethylamino)propyl chloride 
• 108-95-2 phenol 
• 3179-63-3 3-Dimethylamino-1-propanol 
• 105-58-8 Diethyl carbonate 
• 109-55-7 1-amino-3-(dimethylamino)propane 
• 139-02-6 sodium phenoxide 
• 83698-50-4 Trifluoro-methanesulfonate1-(3-dimethylamino-propyl)-2,4,6-triphenyl-pyridinium; 
• 108847-05-8 trimethyl-(3-phenoxy-propyl)-ammonium; iodide 

Downstream Products

• 109-54-6 3-(Dimethylamino)propyl chloride 
• 108-95-2 phenol 
• 20904-18-1 N,N-dimethyl-3-phenoxypropan-1-amine hydrochloride 
• 53929-74-1 N,N-dimethyl-3-bromopropylamine 

Relevant academic research and scientific papers

NOVEL COMPOUND, PREPARATION METHOD THEREOF, AND USE THEREOF

The present invention relates to a method for preparing a biomaterial having selectively functionalized tyrosine, a biomaterial having selectively functionalized tyrosine, and a pharmaceutical composition containing the same as an active ingredient. The method for preparing a biomaterial to which a compound represented by formula 2 is coupled, of the present invention, allows the compound represented by formula 2 to be selectively coupled, in a high yield in a biomaterial, to tyrosine, which is present on the surface of an aqueous solution such that the coupling thereof to amino acids other than tyrosine does not occur and, when only one tyrosine is present, heterogeneous mixtures are not present and the inherent activity of the biomaterial is maintained, and thus the compound can be effectively used as a pharmaceutical composition containing a biomaterial drug as an active ingredient. In addition, the method can selectively functionalize tyrosine, and thus can be effectively used for tyrosine functionalization in a biomaterial.

Mustard Carbonate Analogues as Sustainable Reagents for the Aminoalkylation of Phenols

N,N-dialkyl ethylamine moiety can be found in numerous scaffolds of macromolecules, catalysts, and especially pharmaceuticals. Common synthetic procedures for its incorporation in a substrate relies on the use of a nitrogen mustard gas or on multistep syntheses featuring chlorine hazardous/toxic chemistry. Reported herein is a one-pot synthetic approach for the easy introduction of aminoalkyl chain into different phenolic substrates through dialkyl carbonate (β-aminocarbonate) chemistry. This new direct alcohol substitution avoids the use of chlorine chemistry, and it is efficient on numerous pharmacophore scaffolds with good to quantitative yield. The cytotoxicity via MTT of the β-aminocarbonate, key intermediate of this synthetic approach, was also evaluated and compared with its alcohol precursor.

SALTS OF INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE

Disclosed herein are salts of carbonyl compounds as inhibitors of histone deacetylase (HDAC), useful in treating disease states including cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis,

INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE

Disclosed herein are carbonyl compounds of having the structural formula: or a pharmaceutically acceptable salt, ester, or prodrug thereof, Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.