209158-08-7Relevant academic research and scientific papers
Melanocyte-directed enzyme prodrug therapy (MDEPT): Development of a targeted treatment for malignant melanoma
Jordan, Allan M.,Khan, Tariq H.,Osborn, Helen M. I.,Photiou, Andrew,Riley, Patrick A.
, p. 1775 - 1780 (1999)
A novel prodrug rationally designed to function as a tyrosinase substrate has been synthesised to allow targeted treatment of malignant melanoma. This agent has been evaluated for tyrosinase-mediated drug release, and has been shown to act in the desired
Melanocyte-directed enzyme prodrug therapy (MDEPT): Development of second generation prodrugs for targeted treatment of malignant melanoma
Jordan, Allan M.,Khan, Tariq H.,Malkin, Hugh,Osborn, Helen M.I.,Photiou, Andrew,Riley, Patrick A.
, p. 1549 - 1558 (2007/10/03)
Evaluation of second generation prodrugs for MDEPT, by oximetry, has highlighted structural properties that are advantageous and disadvantageous for efficient oxidation using mushroom tyrosinase. In particular, a sterically undemanding prodrug bis-(2-chlo
