209345-98-2

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 193416-58-9 (2S)-4-[(4-methoxybenzyl)oxy]butane-1,2-diol 
• 195257-54-6 (4S)-4-(2-[(4-methoxybenzyl)oxy]ethyl)-2,2-dimethyl-1,3-dioxolane 
• 824-94-2 p-methoxybenzyl chloride 

Downstream Products

• 209345-86-8 [(1S,5R)-1-Allyl-5-benzyloxy-7-(4-methoxy-benzyloxy)-3-methylene-heptyloxy]-triisopropyl-silane 
• 209345-85-7 (3R,7S)-1-(4-Methoxy-benzyloxy)-5-methylene-7-(tetrahydro-pyran-2-yloxy)-dec-9-en-3-ol 
• 195257-60-4 (2S)-2-[2-(p-methoxybenzyloxy)ethyl]oxirane 

Relevant academic research and scientific papers

Stereocontrolled synthesis of the CD subunit of the marine macrolide altohyrtin A

A synthesis of the C17-C28 segment of altohyrtin A is reported. The synthesis uses a coupling step between two chiral subunits, both of which were synthesized from L-malic acid. The remaining stereocenters were obtained through a combination of stereoselective reactions and thermodynamic equilibration.

IMMUNOMODULATORY GLYCOSPHINGOLIPIDS AND METHODS OF USE THEREOF

Provided herein are a subset of alpha-galactosylceramide (alpha-GC) compounds having improved immunomodulatory activity, particularly with respect to NKT cell number and activity. Also provided herein are methods of use of such compounds, including in the modulation of NKT cells and/or activity in vivo. Further provided are combinatorial synthesis methods for generating alpha-GC compounds of specifically defined structure and thereby generating pure preparations thereof.