Stereocontrolled synthesis of the CD subunit of the marine macrolide altohyrtin A

Article abstract of DOI:10.1016/S0040-4039(98)00686-8

A synthesis of the C17-C28 segment of altohyrtin A is reported. The synthesis uses a coupling step between two chiral subunits, both of which were synthesized from L-malic acid. The remaining stereocenters were obtained through a combination of stereoselective reactions and thermodynamic equilibration.