209807-51-2Relevant academic research and scientific papers
Compounds with analgesic effect
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, (2008/06/13)
Compounds of general formula (I) are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain.
N,N-diethyl-4-(phenylpiperidin-4-ylidenemethyl)benzamide: A novel, exceptionally selective, potent δ opioid receptor agonist with oral bioavailability and its analogues
Wei,Brown,Takasaki,Plobeck,Delorme,Zhou,Yang,Jones,Gawell,Gagnon,Schmidt,Yue,Walpole,Payza,St-Onge,Labarre,Godbout,Jakob,Butterworth,Kamassah,Morin,Projean,Ducharme,Roberts
, p. 3895 - 3905 (2007/10/03)
The design, synthesis, and pharmacological evaluation of a novel class of δ opioid receptor agonists, N,N-diethyl-4-(phenylpiperidin-4-ylidenemethyl)benzamide (6a) and its analogues, are described. These compounds, formally derived from SNC-80 (2) by repl
Probes for narcotic receptor mediated phenomena. 26. Synthesis and biological evaluation of diarylmethylpiperazines and diarylmethylpiperidines as novel, nonpeptidic δ opioid receptor ligands
Zhang, Xiaoyan,Rice, Kenner C.,Calderon, Silvia N.,Kayakiri, Hiroshi,Smith, Larren,Coop, Andrew,Jacobson, Arthur E.,Rothman, Richard B.,Davis, Peg,Dersch, Christina M.,Porreca, Frank
, p. 5455 - 5463 (2007/10/03)
We recently reported (+)-4-[(αR)-α-{(2S,5R)-4-allyl-2,5- dimethyl-1-piperazinyl}-3-methoxybenzyl]-N,N-diethylbenzamide (1b, SNC80) as a novel nonpeptidic δ receptor agonist and explored the structure-activity relationships (SAR) of a series of related der
