209962-07-2

Basic information

• Product Name: (2-bromophenyl)carbonylmorpholine
• Synonyms: (2-Bromophenyl)(morpholino)methanone;(2-bromophenyl)carbonylmorpholine;2-Bromo-1-(morpholinocarbonyl)benzene
• CAS NO: 209962-07-2
• Molecular Formula: C11H12BrNO2
• Molecular Weight: 270.12248
• Mol File: 209962-07-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: (2-bromophenyl)carbonylmorpholine(CAS DataBase Reference)
• NIST Chemistry Reference: (2-bromophenyl)carbonylmorpholine(209962-07-2)
• EPA Substance Registry System: (2-bromophenyl)carbonylmorpholine(209962-07-2)

Safety Data

• Hazardous Substances Data: 209962-07-2(Hazardous Substances Data)

Usage

General Description

(2-bromophenyl)carbonylmorpholine is a chemical compound containing a morpholine ring and a carbonyl group attached to a 2-bromophenyl moiety. It is commonly used as a building block in organic synthesis and is also known for its use as an intermediate in the production of pharmaceuticals and agrochemicals. The compound has been found to exhibit a range of biological activities, including anti-inflammatory, antifungal, and anticancer properties, making it a valuable target for drug discovery and development. Additionally, (2-bromophenyl)carbonylmorpholine has potential applications in materials science and as a reagent in chemical research. Overall, this compound possesses diverse and promising properties that make it an important and versatile molecule in various fields of science and industry.

Upstream product

• 95-56-7 2-hydroxybromobenzene 
• 110-91-8 morpholine 
• 201230-82-2 carbon monoxide 
• 129112-25-0 2-(trifluoromethanesulfonyl)oxy-bromobenzene 
• 88-65-3 2-bromobenzoic-acid 
• 7154-66-7 2-bromobenzoic acid chloride 
• 6630-33-7 ortho-bromobenzaldehyde 
• 6091-64-1 2-bromobenzoic acid ethyl ester 

Relevant articles and documents

Ligand- and Solvent-Tuned Chemoselective Carbonylation of Bromoaryl Triflates

The palladium-catalyzed chemoselective carbonylation of bromoaryl triflates is reported. The selective C?Br bond versus C?OTf (OTf=triflate) bond functionalization can be remarkably tuned by the combination of the ligand [4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (Xantphos) vs. 1,1′-bis(diphenylphosphino)ferrocene (DPPF)] and the solvent (toluene vs. DMSO). The respective ligand and solvent effects are rationalized by DFT calculations. In contrast, the monodentate ligands BuPAd2 and tBu3P prefer the selective C?Br bond activation and are solvent insensitive.

Rhodium-catalyzed oxidative amidation of allylic alcohols and aldehydes: Effective conversion of amines and anilines into amides

The rhodium-catalyzed oxidative amidation of allylic alcohols and aldehydes is reported. In situ generated [(BINAP)Rh]BF4 catalyzes the one-pot isomerization/oxidative amidation of allylic alcohols or direct amidation of aldehydes using acetone or styrene as the hydrogen acceptor. The conditions are general, affording good to excellent yields with a wide array of amine and aniline nucleophiles, and chemoselective, other alcohols do not participate in the oxidation reaction. Utilization of biphasic conditions is critical, as they promote an equilibrium between the imine/enamine byproducts and the hemiaminal, which can undergo oxidation to the amide.