210481-32-6Relevant academic research and scientific papers
Efficient Synthesis of α-Trifluoromethyl Carboxylic Acids and Esters through Fluorocarboxylation of gem-Difluoroalkenes
Yoo, Woo-Jin,Kondo, Junpei,Rodríguez-Santamaría, José A.,Nguyen, Thanh V. Q.,Kobayashi, Shū
supporting information, p. 6772 - 6775 (2019/04/17)
A facile synthetic procedure for the preparation of α-trifluoromethyl carboxylic acids and esters was achieved through multicomponent coupling reactions between gem-difluoroalkenes, cesium fluoride, and carbon dioxide. The products were generated in moderate to excellent yields, and the synthetic utility of this method was demonstrated through the preparation of trifluoromethylated versions of popular nonsteroidal anti-inflammatory drugs (NSAIDs).
Copper-mediated trifluoromethylation of α-diazo esters with TMSCF3: The important role of water as a promoter
Hu, Mingyou,Ni, Chuanfa,Hu, Jinbo
supporting information, p. 15257 - 15260 (2012/10/29)
Copper-mediated trifluoromethylation of α-diazo esters with TMSCF3 reagent has been developed as a new method to prepare α-trifluoromethyl esters. This trifluoromethylation reaction represents the first example of fluoroalkylation of a non-fluorinated carbene precursor. Water plays an important role in promoting the reaction by activating the "CuCF3" species prepared from CuI/TMSCF3/CsF (1.0:1.1:1.1). The scope of this trifluoromethylation reaction is broad, and its efficiency is demonstrated in the synthesis of a variety of aryl-, benzyl-, and alkyl-substituted 3,3,3-trifluoropropanoates.
Efficient one step procedure for the synthesis of α- trifluoromethylated arylacetates
Jeong, Howa,Park, Tae Won,Kim, Bum Tae
, p. 1981 - 1987 (2007/10/03)
The reaction of β,β-difluoro-α-trifluoromethylstyrene derivatives 1 with 3 equiv. of sodium methoxide in acetonitrile at 25°C afforded a- trifluoromethylated arylacetates 3 in good yields.
