28321-09-7

Basic information

• Product Name: Benzene, 1-chloro-4-(2,2-difluoroethenyl)-
• CAS NO: 28321-09-7
• Molecular Formula: C8H5ClF2
• Molecular Weight: 174.578
• Mol File: 28321-09-7.mol
• Article Data: 29

Chemical Properties

• CAS DataBase Reference: Benzene, 1-chloro-4-(2,2-difluoroethenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-chloro-4-(2,2-difluoroethenyl)-(28321-09-7)
• EPA Substance Registry System: Benzene, 1-chloro-4-(2,2-difluoroethenyl)-(28321-09-7)

Safety Data

• Hazardous Substances Data: 28321-09-7(Hazardous Substances Data)

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 19740-19-3 chlorodifluoroacetic acid lithium salt 
• 75-61-6 dibromodifluoromethane 
• 52372-80-2 (4-chlorobenzylidene)hydrazine 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 87189-16-0 potassium 2-bromo-2,2-difluoroacetate 
• 1679-18-1 4-Chlorophenylboronic acid 
• 2236129-81-8 trifluoroacetaldehyde N-triftosylhydrazone 
• 680-15-9 2,2-difluoro-2-(fluorosulfonyl)acetate 
• 51044-12-3 (4-chlorobenzyl)triphenylphosphonium bromide 
• 38897-99-3 (4-Chlorophenylmethylene)triphenylphosphorane 
• 371-67-5 2,2,2-trifluorodiazoethane 
• 58310-28-4 (Difluoromethyl)triphenylphosphonium bromide 
• 1600503-70-5 potassium 2-pyridinyl sulfonyl-difluoroacetate 

Downstream Products

• 75280-14-7 1-Chloro-2-(4-chloro-phenyl)-1,1-difluoro-pentan-3-one 
• 81577-07-3 1-chloro-4-(2,2,2-trifluoroethyl)benzene 
• 43020-12-8 1-(5-(4-chlorophenyl)-2-methylfuran-3-yl)ethanone 
• 78999-22-1 [2-(4-Chloro-phenyl)-1,1-difluoro-ethylsulfanyl]-acetic acid ethyl ester 

Relevant articles and documents

Stereoselective formation of Z-monofluoroalkenes by nickel-catalyzed defluorinative coupling of gem?difluoroalkenes with lithium organoborates

A method for stereoselective construction of Z-monofluoroalkenes by nickel-catalyzed defluorinative coupling of gem?difluoroalkenes in mild conditions was described. The combination of lithium organoborate and ZnBr2 generated in situ lithium ar

-Annulation of gem-Difluoroalkenes and Pyridinium Ylides: Access to Functionalized 2-Fluoroindolizines

A [3 + 2]-annulation of gem-difluoroalkenes and pyridinium ylides was developed employing ambient air as the sole oxidant in an open-vessel manner, affording a series of multifunctionalized 2-fluoroindolizines in moderate to good yields. In this reaction, gem-difluoroalkene acts as a C2 synthon and entirely avoids the competitive addition-elimination process, which provides facile access to 2-fluoroindolizines.

Design and Synthesis of TY-Phos and Application in Palladium-Catalyzed Enantioselective Fluoroarylation of gem-Difluoroalkenes

The first example of highly enantioselective fluoroarylation of gem-difluoroalkenes with aryl halides is presented by using a new chiral sulfinamide phosphine (Sadphos) type ligand TY-Phos. N-Me-TY-Phos can be easily synthesized on a gram scale from readily available starting materials in three steps. Salient features of this work including readily available starting materials, good yields, high enantioselectivities as well as broad substrate scope make this approach very practical and attractive. Notably, the asymmetric synthesis of an analogue of a biologically active molecule is also reported.