210694-04-5

Upstream product

• 2346-07-8 neopentyl tosylate 
• 123-08-0 4-hydroxy-benzaldehyde 
• 75-84-3 2,2-dimethyl-propanol-1 
• 123-11-5 4-methoxy-benzaldehyde 
• 528528-58-7 1-bromo-4-(2,2-dimethylpropoxy)benzene 
• 68-12-2 N,N-dimethyl-formamide 
• 210693-55-3 [(+/-)-BINAP]Pd(p-C₆H₄CHO)(OCH₂CMe₃) 
• 14225-16-2 4-(2,2-dimethylpropyloxy)nitrobenzene 
• 623-00-7 4-bromobenzenecarbonitrile 
• 79615-68-2 4-(neopentyloxy)benzonitrile 
• 85259-07-0 (E)-3-[4-(2,2-Dimethyl-propoxy)-phenyl]-acrylic acid 

Downstream Products

• 85258-83-9 5-[4-(2,2-Dimethyl-propoxy)-phenyl]-thiazolidine-2,4-dione 

Relevant academic research and scientific papers

3-PHENYL-4-HEXYNOIC ACID DERIVATIVES AS GPR40 AGONISTS

A compound of the formula (I)wherein R represents a straight or branched, primary or secondary acyclic hydrocarbyl C3–C15 group, which can be saturated or unsaturated, or a straight or branched, primary or secondary acyclic hydrocarbyl C3–C15 group, which can be saturated or unsaturated and wherein one or more of hydrogen atoms is replaced with fluorine atom; X represents hydrogen atom or halogen atom,and* denotes chiral center, and salts thereof. The compound is useful for the treatment of diseases mediated by GPR40, in particular type II diabetes. (I)

Phosphazene Base tBu-P4 Catalyzed Methoxy–Alkoxy Exchange Reaction on (Hetero)Arenes

The organic superbase tBu-P4 catalyzes methoxy-alkoxy exchange reactions on (hetero)arenes with alcohols. The catalytic reaction proceeded efficiently with electron-deficient methoxy(hetero)arenes as well as with a variety of alcohols, including 3-amino-1-propanol, β-citronellol, menthol, and cholesterol. An intramolecular version of this reaction furnished six- and seven-membered ring compounds.

ANTIBACTERIAL AGENTS: ARYL MYXOPYRONIN DERIVATIVES

The invention provides compounds of formula la, lb and Ic: [Formula Ia, Ib, and Ic] and salts thereof, wherein variables are as described in the specification, as well as compositions comprising a compound of formula Ia-Ic, methods of making such compounds, and methods of using such compounds, e.g., as inhibitors of bacterial RNA polymerase and as antibacterial agents.

One-pot synthesis of terpyridines and macrocyclization to C3-symmetric cyclosexipyridines

Four examples of 2,6-dicinnamoylpyridines were obtained in 60-65% yields in condensations of commercially available 2,6-diacetylpyridine and benzaldehydes in 1:2 stoichiometry. At 2:1 ratios, four related 6,6″-diacetylated-4′-arylterpyridines were isolate

Electronic dependence of C-O reductive elimination from palladium (aryl)neopentoxide complexes

Thermal decomposition of the palladium (aryl)neopentoxide complexes [P-P]Pd(Ar)OCH2CMe3 [P-P =Tol-BINAP or BINAP; Ar p-C6H4CHO (1b), p-C6H4COPh (1c), p-C6H4NO2 (1d), o-C6H4NO2 (1e), o-C6H4CN (1F)] possessing substituents on the palladium-bound aryl group suitable for delocalization of negative charge led to quantitative (≤95%) formation of aryl ether without detectable β-hydride elimination. Thermal decomposition of 1b-f obeyed first-order kinetics, and the rate of reductive elimination decreased in the order o-NO2 > p-NO2 > p-CHO > p-COPh > o-CN. Conversely, thermal decomposition of the related derivatives [P-P]Pd(Ar)OCH2CMe3 [P-P = Tol-BINAP or BINAP; Ar p-C6H4Cl (1g), m-C6H4NO2 (1h), m-C6H4CN (1i)] which did not possess a resonance stabilizing group on the palladium-bound aryl group led to no detectable formation of aryl ether. These and related data point to the buildup of negative charge in the palladium-bound aryl group in the transition state for C-O reductive elimination and are consistent with a mechanism initiated by inner-sphere nucleophilic attack of the alkoxide ligand at the ipso-carbon atom of the palladium-bound aryl group through a zwitterionic Meisenheimer-type intermediate or transition state.