474012-75-4

Upstream product

• 474012-67-4 4-(6-bromo-imidazo[1,2-a]pyridin-2-yl)-N,N-dimethylbenzenamine 
• 20511-12-0 2-amino-5-iodopyridine 
• 37904-72-6 2-bromo-1-(4-(dimethylamino)phenyl)ethanone 
• 210832-81-8 2,2-dibromo-1-(4-(dimethylamino)phenyl)ethan-1-one 
• 2124-31-4 4'-dimethylaminoacetophenone 

Downstream Products

• 893475-31-5 dimethyl-[4-(6-vinyl-imidazo[1,2-a]pyridin-2-yl)-phenyl]-amine 
• 14954-72-4 2-(4′-dimethylaminophenyl)-6-imidazo[1,2-a]pyridine 
• 917763-56-5 6-(2-fluoroethoxy)-2-(4-dimethylaminophenyl)-imidazo[1,2-a]pyridine 
• 955376-52-0 C₁₉H₂₁N₃O₂S 
• 893475-53-1 toluene-4-sulfonic acid 3-[2-(4-dimethylamino-phenyl)-imidazo[1,2-a]pyridin-6-yl]-propyl ester 
• 893475-42-8 3-[2-(4-dimethylamino-phenyl)-imidazo[1,2-a]pyridin-6-yl]-propan-1-ol 
• 893475-38-2 2-[2-(4-dimethylamino-phenyl)-imidazo[1,2-a]pyridin-6-yl]-ethanol 
• 893475-34-8 [4-(6-allyl-imidazo[1,2-a]pyridin-2-yl)-phenyl]-dimethyl-amine 

Relevant academic research and scientific papers

Radiosynthesis of SPECT tracers: Via a copper mediated 123I iodination of (hetero)aryl boron reagents

A general method for the copper mediated nucleophilic 123I-iodination of (hetero)aryl boronic esters and acids has been developed. The broad substrate scope of this radiosynthetic approach allows access to [123I]DPA-713, [123I]IMPY, [123I]MIBG and [123I]IPEB that are four commonly used SPECT radiotracers. Our results infer that aryl boronic reagents can now be employed as common precursors for both fluorine-18 and iodine-123 radiolabelling.

BETA-AMYLOID PET IMAGING AGENTS

Novel derivatives of imidazopyridinylbenzeneamines and novel derivatives of benzothiazolylbenzeneamines are disclosed that offer improved behavior when used as imaging agents for positron emission tomography of beta-amyloids. Also disclosed is a palladium-catalyzed reaction scheme under microwave conditions for aryl thioethers in general that provides a high ratio of substitution relative to reduction and can be used for the imidazopyridinylbenzeneamine derivatives as well as other compounds of related structure.

Synthesis and evaluation of two 18F-labeled imidazo[1,2-a]pyridine analogues as potential agents for imaging β-amyloid in Alzheimer's disease

Two new fluorinated imidazo[1,2-a]pyridine derivatives, 6-(2′-fluoroethyl)-2-(4′-dimethylamino)phenylimidazo[1,2-a]pyridine (FEPIP) and 6-(3′-fluoropropyl)-2-(4′-dimethylamino)phenylimidazo[1,2-a]pyridine (FPPIP), were synthesized. The binding affinity fo

Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting β-amyloid plaques in the brain

A series of novel β-amyloid (Aβ) aggregate-specific ligands, 2-(4′-dimethylaminophenyl)-6-iodoimidazo[1,2-a]pyridine, 16(IMPY), and its related derivatives were prepared. An in vitro binding study with preformed Aβ aggregates showed that 16(IMPY) and its