2108567-79-7Relevant academic research and scientific papers
Chemical and pharmacological characterization of the TRPML calcium channel blockers ML-SI1 and ML-SI3
Leser, Charlotte,Keller, Marco,Gerndt, Susanne,Urban, Nicole,Chen, Cheng-Chang,Schaefer, Michael,Grimm, Christian,Bracher, Franz
, (2021)
The members of the TRPML subfamily of non-selective cation channels (TRPML1-3) are involved in the regulation of important lysosomal and endosomal functions, and mutations in TRPML1 are associated with the neurodegenerative lysosomal storage disorder muco
Effective chiral pool synthesis of both enantiomers of the TRPML inhibitor trans-ML-SI3
Kriegler, Katharina,Leser, Charlotte,Mayer, Peter,Bracher, Franz
, (2021/11/10)
Two independent chiral pool syntheses of both enantiomers of the TRPML inhibitor, trans-ML-SI3, were developed, starting from commercially available (1S,2R)- and (1R,2S)-configured cis-2-aminocyclohexanols. Both routes lead to the target compounds in exce
