291533-28-3

Usage

Uses

Used in Pharmaceutical Industry:
Carbamic acid, [(1R,2S)-2-hydroxycyclohexyl]-, 1,1-dimethylethyl ester (9CI) is used as a precursor for the synthesis of various pharmaceuticals, particularly those used in the treatment of neurological disorders.
Used in Organic Synthesis:
Carbamic acid, [(1R,2S)-2-hydroxycyclohexyl]-, 1,1-dimethylethyl ester (9CI) is utilized as a reagent in organic synthesis, contributing to the development of new chemical compounds.
Used in Production of Complex Chemicals:
Carbamic acid, [(1R,2S)-2-hydroxycyclohexyl]-, 1,1-dimethylethyl ester (9CI) serves as a building block in the production of other complex chemicals, enhancing the diversity of chemical structures and applications.
It is important to handle and use Carbamic acid, [(1R,2S)-2-hydroxycyclohexyl]-, 1,1-dimethylethyl ester (9CI) with caution, following proper safety guidelines and procedures to ensure safe and effective applications.

Upstream product

• 34619-03-9 tert-butyldicarbonate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 189942-50-5 (3aR,7aS)-hexahydrobenzo[d]oxazol-2(3H)-one 
• 155975-19-2 (1R,2R)-trans-2-(N-tert-butyloxycarbonyl)amino-1-cyclohexanol 
• 291533-10-3 2-(tert-butoxycarbonylamino)cyclohexanone 
• 477584-30-8 ((1S,2R)-2-Hydroxy-cyclohexyl)-carbamic acid tert-butyl ester 
• 108267-20-5 cis-2-amino-cyclohexanol 

Downstream Products

• 214679-17-1 (1S,2R)-(-)-1-tert-butoxycarbonylaminocyclohexan-2-ol 
• 2108567-79-7 N-{(1R,2R)-2-[4-(2-methoxyphenyl)piperazin-1-yl]cyclohexyl}benzenesulfonamide 
• 2108567-79-7 N-{(1S,2S)-2-[4-(2-methoxyphenyl)piperazin-1-yl]cyclohexyl}benzenesulfonamide 
• 187333-96-6 (1S,2R)-2-(benzyloxycarbonylamino)cyclohexan-1-ol 

Relevant academic research and scientific papers

Effective chiral pool synthesis of both enantiomers of the TRPML inhibitor trans-ML-SI3

Two independent chiral pool syntheses of both enantiomers of the TRPML inhibitor, trans-ML-SI3, were developed, starting from commercially available (1S,2R)- and (1R,2S)-configured cis-2-aminocyclohexanols. Both routes lead to the target compounds in exce

MACROCYCLIC COMPOUNDS AS KINASES INHIBITORS AND USES THEREOF

The present disclosure describes kinases (ALK, ROS1, and TRK) inhibitors and their uses. The pharmaceutical compositions comprising such kinase inhibitors and methods of using them for treating cancer, infectious diseases, and other disorders are also des

COMPOUNDS, COMPOSITIONS AND METHODS FOR SYNTHESIS

The present disclosure, among other things, provides technologies for synthesis, including reagents and methods for stereoselective synthesis. In some embodiments, the present disclosure provides compounds useful as chiral auxiliaries. In some embodiments, the present disclosure provides reagents and methods for oligonucleotide synthesis. In some embodiments, the present disclosure provides reagents and methods for chirally controlled preparation of oligonucleotides. In some embodiments, technologies of the present disclosure are particularly useful for constructing challenging internucleotidic linkages, providing high yields and stereoselectivity.

Synthesis of chiral aminophosphines from chiral aminoalcohols via cyclic sulfamidates

(Chemical Equation Presented) Protic aminophosphines with multiple chiral centers were synthesized in good yields and high purity by the nucleophilic ring-opening of N-protected cyclic sulfamidates with metal phosphides, followed by hydrolysis and deprote

Kinetic resolution of amino alcohol derivatives with a chiral nucleophilic catalyst: Access to enantiopure cyclic cis-amino alcohols

Acylative kinetic resolution of racemic cyclic cis-amino alcohol derivatives with a chiral nucleophilic catalyst proceeds enantioselectively (s = 10-21) at ambient temperature to give enantiopure recovered materials, and the % conversion of the acylation can be readily controlled by the amount of acid anhydride.

Facile inversion of configuration of N-Boc-β-aminoalcohols via S(N)2 cyclization to oxazolidinones

Oxazolidinones are obtained by the cyclization of mesylates derived from N-Boc-β-Aminoalcohols. Hydrolysis of the N-Boc-Oxazolidinones regenerates the protected aminoalcohols with inverted configuration at the hydroxy group. (C) 2000 Elsevier Science Ltd.