210891-04-6

Basic information

• Product Name: Edonentan
• Synonyms: Edonentan;BMS 207940;N-[[2-[2-[(4,5-dimethyl-1,2-oxazol-3-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-N,3,3-trimethylbutanamide
• CAS NO: 210891-04-6
• Molecular Formula: C28H32N4O5S
• Molecular Weight: 536.65
• Mol File: 210891-04-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 732.9°Cat760mmHg
• Flash Point: 397.1°C
• Appearance: /
• Density: 1.248g/cm³
• CAS DataBase Reference: Edonentan(CAS DataBase Reference)
• NIST Chemistry Reference: Edonentan(210891-04-6)
• EPA Substance Registry System: Edonentan(210891-04-6)

Safety Data

• Hazardous Substances Data: 210891-04-6(Hazardous Substances Data)

Usage

Uses

Treatment of heart failure (endothelin A(ETA) inhibitor).

Upstream product

• 210891-12-6 N-(4,5-Dimethyl-3-isoxazolyl)-2'-formyl-4'-(2-oxazolyl)[1,1'-biphenyl]-2-sulfonamide 
• 195447-73-5 2-Bromo-N-(4,5-dimethyl-3-isoxazolyl)-N-[(2-methoxyethoxy)methyl]-benzenesulfonamide 
• 13999-39-8 4,5-dimethyl-1,2-oxazol-3-amine 
• 2905-25-1 o-bromobenzenesulfonyl chloride 
• 7065-46-5 3,3-dimethylbutanoic acid chloride 
• 210891-13-7 N-(4,5-dimethyl-3-isoxazolyl)-2'-[(methylamino)methyl]-4'-(2-oxazolyl)[1,1'-biphenyl]-2-sulfonamide 
• 195447-74-6 N-(4,5-dimethyl-3-isoxazolyl)-2'-formyl-N-[(2-methoxyethoxy)methyl]-4'-(2-oxazolyl)[1,1'-biphenyl]-2-sulfonamide 
• 195447-72-4 N-(4,5-dimethyl-3-isoxazolyl)-2-bromobenzenesulfonamide 
• 254746-77-5 [2-[[(4,5-dimethyl-3-isoxazolyl)[(2-methoxyethoxy)methyl]amino]-sulfonyl]phenyl]boronic acid 

Relevant articles and documents

Biphenylsulfonamide endothelin receptor antagonists. 4. Discovery of N-[[2′-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4- (2-oxazolyl)[1,1′-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), a highly potent and orally active ETA s

We have previously disclosed the selective ETA receptor antagonist N-(3,4-dimethyl-5-isoxazolyl)-4′-(2-oxazolyl)[1,1′- biphenyl]-2-sulfonamide (1, BMS-193884) as a clinical development candidate. Additional SAR studies at the 2′-position of 1 l

Methods for the preparation of biphenyl isoxazole sulfonamides

Methods for the preparation of biphenyl isoxazole sulfonamides and intermediates thereof. The present invention also relates to the novel intermediates prepared by these methods. The biphenyl isoxazole sulfonamides prepared by the present methods are endo