254746-77-5 Usage
Uses
Used in Pharmaceutical Research:
[2-[[(4,5-dimethyl-3-isoxazolyl)[(2-methoxyethoxy)methyl]amino]-sulfonyl]phenyl]boronic acid is used as a potential ligand in pharmaceutical research for the development of new drugs. Its unique structure and functional groups allow it to bind to biological molecules such as proteins and enzymes, making it a valuable tool in the design and synthesis of novel therapeutic agents.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, [2-[[(4,5-dimethyl-3-isoxazolyl)[(2-methoxyethoxy)methyl]amino]-sulfonyl]phenyl]boronic acid is used as a versatile compound for the exploration of new drug candidates. Its ability to interact with biological targets and its complex structure make it a valuable asset in the search for innovative treatments for various diseases and conditions.
Used in Chemical Synthesis:
[2-[[(4,5-dimethyl-3-isoxazolyl)[(2-methoxyethoxy)methyl]amino]-sulfonyl]phenyl]boronic acid is also utilized in chemical synthesis, where its unique structure and functional groups can be employed to create new compounds with potential applications in various industries, including pharmaceuticals, materials science, and agrochemicals.
Used in Biochemical Research:
In biochemical research, [2-[[(4,5-dimethyl-3-isoxazolyl)[(2-methoxyethoxy)methyl]amino]-sulfonyl]phenyl]boronic acid serves as a valuable tool for studying the interactions between biological molecules and potential drug candidates. Its ability to bind to proteins and enzymes can provide insights into the mechanisms of action and help guide the development of more effective therapeutic agents.
Used in Drug Delivery Systems:
Similar to its application in pharmaceutical research, [2-[[(4,5-dimethyl-3-isoxazolyl)[(2-methoxyethoxy)methyl]amino]-sulfonyl]phenyl]boronic acid can be employed in the development of drug delivery systems. Its unique structure and functional groups can be utilized to improve the delivery, bioavailability, and therapeutic outcomes of various drugs, potentially enhancing their efficacy and reducing side effects.
Used in the Chemical Industry:
[2-[[(4,5-dimethyl-3-isoxazolyl)[(2-methoxyethoxy)methyl]amino]-sulfonyl]phenyl]boronic acid can be used in the chemical industry for the synthesis of various compounds with potential applications in materials science, agrochemicals, and other fields. Its complex structure and functional groups make it a versatile building block for the creation of new molecules with specific properties and functions.
Check Digit Verification of cas no
The CAS Registry Mumber 254746-77-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,5,4,7,4 and 6 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 254746-77:
(8*2)+(7*5)+(6*4)+(5*7)+(4*4)+(3*6)+(2*7)+(1*7)=165
165 % 10 = 5
So 254746-77-5 is a valid CAS Registry Number.
254746-77-5Relevant academic research and scientific papers
ENDOTHELIN ANTAGONISTS: N- 2'- (4,5-DIMETHYL-3-ISOXAZOLYL) AMINO]SULFONYL]-4-(2-OXAZOLYL) 1,1'-BIPHENYL]-2-YL]METHYL] -N,3,3-TRIMETHYLBUTANAMIDE AND N-(4,5-DIMETHYL-3-ISOXAZOLYL) -2'- (3,3-DIMETHYL-2-OXO-1-PYRROLIDINYL) METHYL] -4'-(2-OXAZOLYL) 1,1'-BIPHE
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Page/Page column 6, (2010/02/03)
The compounds N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphenyl]-2-sulfon
Biphenylsulfonamide endothelin receptor antagonists. 4. Discovery of N-[[2′-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4- (2-oxazolyl)[1,1′-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), a highly potent and orally active ETA s
Murugesan, Natesan,Gu, Zhengxiang,Spergel, Steven,Young, Marian,Chen, Ping,Mathur, Arvind,Leith, Leslie,Hermsmeier, Mark,Liu, Eddie C.-K.,Zhang, Rongan,Bird, Eileen,Waldron, Tom,Marino, Anthony,Koplowitz, Barry,Humphreys, W. Griffith,Chong, Saeho,Morrison, Richard A.,Webb, Maria L.,Moreland, Suzanne,Trippodo, Nick,Barrish, Joel C.
, p. 125 - 137 (2007/10/03)
We have previously disclosed the selective ETA receptor antagonist N-(3,4-dimethyl-5-isoxazolyl)-4′-(2-oxazolyl)[1,1′- biphenyl]-2-sulfonamide (1, BMS-193884) as a clinical development candidate. Additional SAR studies at the 2′-position of 1 l
Isoxazolyl endothelin antagonists
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, (2008/06/13)
The compounds N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphenyl]-2-sulfon
Substituted biphenyl isoxazole sulfonamides
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, (2008/06/13)
Compounds of the formula STR1 inhibit the activity of endothelin. The symbols are defined as follows: R1, R2, R3 and R4 are each directly bonded to a ring carbon and are each independently (a) hydrogen; (b) alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, aryloxy, aralkyl or aralkoxy, any of which may be substituted with Z1, Z2 and Z3 ; (c) halo; (d) hydroxyl; (e) cyano; (f) nitro; (g) --C(O)H or --C(O)R5 ; (h) --CO2 H or --CO2 R5 ; (i) --Z4 --NR6 R7 ; (j) --Z4 --N(R10)--Z5 --NR8 R9 ; or (k) R3 and R4 together may also be alkylene or alkenylene, either of which may be substituted with Z1, Z2 and Z3, completing a 4- to 8-membered saturated, unsaturated or aromatic ring together with the carbon atoms to which they are attached; and the remaining symbols are as defined in the specification.
