2109-84-4

Usage

Molecular weight

225.21 g/mol

Physical state

Yellow crystalline solid

Chemical properties

a. Ability to undergo nucleophilic substitution reactions
b. Ability to undergo cross-coupling reactions

Applications

a. Starting material in organic synthesis
b. Reagent in chemical reactions
c. Precursor for the synthesis of pharmaceutical compounds

Safety precautions

Toxic if ingested, inhaled, or comes into contact with skin

Upstream product

• 1111-97-3 3-chloro-3-methylbut-1-yne 
• 100-02-7 4-nitro-phenol 
• 19021-53-5 methyl (2-methylbut-3-yn-2-yl)carbonate 
• 61570-79-4 1,1-dimethyl-2-propynyl trifluoroacetate 
• 115-19-5 2-methyl-but-3-yn-2-ol 
• 350-46-9 4-Fluoronitrobenzene 
• 636-98-6 p-nitrobenzene iodide 
• 905718-45-8 [(4-nitrophenyl)(phenyl)iodonium trifluoromethanesulfonate] 
• 50965-91-8 sodium salt of 1,1-dimethylpropynol 

Downstream Products

• 86824-20-6 (3R,4S)-2,2-Dimethyl-6-nitro-4-(4-phenyl-piperazin-1-yl)-chroman-3-ol 
• 1417919-60-8 (hexacarbonyldicobalt)-2-methyl-3-butyn-2-yl para-nitrophenyl ether 
• 33143-28-1 6-nitro-2,2-dimethyl chromene 

Relevant academic research and scientific papers

Mild synthesis of sterically congested alkyl aryl ethers

An efficient and transition-metal-free method is presented to access tertiary alkyl aryl ethers by arylation of tertiary alcohols with ortho-substituted diaryliodonium salts. The scope covers cyclic and acyclic aliphatic, benzylic, allylic, and propargyli

Copper-catalyzed intramolecular carbotrifluoromethylation of alkynes for the construction of trifluoromethylated heterocycles

A mild and efficient copper-catalyzed intramolecular carbotrifluoromethylation of alkynes has been achieved in the presence of Togni reagent as trifluoromethylating reagent. The reaction tolerates a range of substrates to give a group of trifluoromethylated heterocycles with high selectivities. A plausible mechanism was proposed on the basis of experimental results. And the Togni award goes to Copper-catalyzed intramolecular carbotrifluoromethylation of alkynes is carried out with a Togni reagent as the trifluoromethylating reagent (see scheme). Various trifluoromethylated heterocycles are synthesized in moderate to good yields. Moreover, a range of common functional groups is tolerated under the reaction conditions.

Asymmetric epoxidation of alkenes catalyzed by a porphyrin-inspired manganese complex

A novel strategy for catalytic asymmetric epoxidation of a wide variety of olefins by a porphyrin-inspired chiral manganese complex using H 2O2 as a terminal oxidant in excellent yield with up to greater than 99% ee has been successfully developed.

Anticancer (hexacarbonyldicobalt)propargyl aryl ethers: Synthesis, antiproliferative activity, apoptosis induction, and effect on cellular oxidative stress

While an increasing number of (hexacarbonyldicobalt)alkynes have been found to possess antiproliferative activity against a number of cancer cell lines, the role of the organometallic moiety in this bioactivity is not well understood. To gain a better und

Asymmetric counteranion-directed transition-metal catalysis: Enantioselective epoxidation of alkenes with Manganese(III) salen phosphate complexes

(Figure Presented) Figure Presentation Paired up: A highly active and enantioselective ion-pair epoxidation catalyst, consisting of an achiral Mn |||-salen complex and a chiral phosphate counteranion, mediates the epoxidization of a wide range of alkenes with high yields and enantioselectivities (see scheme). The unique role of the counteranion is to stabilize an enantiomorphic conformation of the cationic Mn catalyst.

PROCESS FOR PRODUCTION OF AN ACETYLENIC COMPOUND

There is provided a process for producing an acetylene compound useful as an intermediate of pharmaceuticals, from 4-nitrofluorobenzene, in industrially and economically advantageous manner. Concretely, it is a method for producing an acetylene compound o

Copper(I) iodide: A catalyst for the improved synthesis of aryl propargyl ethers

Copper(I) iodide catalyses the reaction between phenols and dialkylpropargyl chlorides to give aryl 1,1-dialkylpropargyl ethers 5 a-k and 7a-e in good yields and purity. These ethers are important as precursors to the 2H-1-benzopyrans 8a-l and 9a-e.

Improved Synthesis of Aryl 1,1-Dimethylpropargyl Ethers

An efficient, general, and practical synthesis of aryl 1,1-dimethylpropargyl ethers has been developed.

The Synthesis and Potassium Channel Blocking Activity of Some (4-Methanesulfonamidophenoxy)propanolamines as Potential Class III Antiarrhythmic Agents

The synthesis of 22 (4-methanesulfonamidophenoxy)propanolamines and their testing on isolated guinea pig cardiac myocytes, on isolated preparations from guinea pig atria, and on rat blood pressure are described.Secondary amines in the series (11a-f) showe

A FACILE SYNTHESIS OF ARYL ETHERS OF ETHYNYLCARBINOLS USING THE MITSUNOBU REACTION

The facile synthesis of a few aryl ethers of ethynylcarbinols using the Mitsunobu reaction is reported.