2110-18-1

Basic information

• Product Name: 2-(3-PHENYLPROPYL)PYRIDINE
• Synonyms: 2-(3-phenylpropyl)-pyridin;AKOS 90304;1-PHENYL-3-(2-PYRIDYL)PROPANE;2-(3-PHENYLPROPYL)PYRIDINE;FEMA 3751;FEMA NUMBER 3751;2-(3-PHENYLPROPYL)PYRIDINE 97+%;CORPS RACINE
• CAS NO: 2110-18-1
• Molecular Formula: C₁₄H₁₅N
• Molecular Weight: 197.28
• EINECS: 218-300-7
• Product Categories: Alphabetical Listings;Flavors and Fragrances;O-P
• Mol File: 2110-18-1.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 142-143 °C1 mm Hg(lit.)
• Flash Point: 212 °F
• Appearance: Clear yellow/Liquid
• Density: 1.015 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00257mmHg at 25°C
• Refractive Index: n20/D 1.56(lit.)
• PKA: 5.80±0.12(Predicted)
• CAS DataBase Reference: 2-(3-PHENYLPROPYL)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-PHENYLPROPYL)PYRIDINE(2110-18-1)
• EPA Substance Registry System: 2-(3-PHENYLPROPYL)PYRIDINE(2110-18-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• WGK Germany: 2
• TSCA: Yes
• Hazardous Substances Data: 2110-18-1(Hazardous Substances Data)

Usage

Chemical Properties

Clear yellow liquid

Taste threshold values

Taste characteristics at 1 ppm: green, vegetative and jalape?o pepper-like with some savory metallic nuances.

InChI:InChI=1/C14H15N/c1-2-7-13(8-3-1)9-6-11-14-10-4-5-12-15-14/h1-5,7-8,10,12H,6,9,11H2

Upstream product

• 109-06-8 α-picoline 
• 100-42-5 styrene 
• 622-24-2 2-phenylethyl chloride 
• 100-69-6 2-vinylpyridine 
• 108-88-3 toluene 
• 108-86-1 bromobenzene 
• 7439-93-2 lithium 
• 103-63-9 1-phenyl-2-bromoethane 
• 109-09-1 2-chloropyridine 
• 329685-40-7 4,4,5,5-tetramethyl-2-(3-phenylpropyl)-[1,3,2]dioxaborolane 
• 109-04-6 2-bromo-pyridine 
• 300-57-2 allylbenzene 
• 4463-42-7 benzyl boronic acid 
• 100-52-7 benzaldehyde 

Downstream Products

• 116602-63-2 1-benzyl-2-(3-phenyl-propyl)-pyridinium; chloride 
• 115145-56-7 1-methyl-2-(3-phenyl-propyl)-pyridinium; toluene-4-sulfonate 
• 99112-96-6 2-(3-phenyl-propyl)-piperidine 
• 56741-25-4 1-phenyl-3-(pyridin-2-yl)propan-1-one 
• 54313-85-8 3-phenyl-1-(pyridin-2-yl)propan-1-one 
• 1422450-71-2 2-[3-phenyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propyl]pyridine 
• 1422450-64-3 2-benzyl-3-(pyridin-2-yl)propan-1-ol 
• 1079883-77-4 2-(3,5-dimethylphenyl)-6-(3-phenylpropyyl)-pyridine 
• 365552-55-2 4-(1-phenethyl-indolizin-2-yl)-phenol 

Relevant articles and documents

Ligand-controlled, Pd/CuH-catalyzed reductive cross-coupling of terminal alkenes and: N -heteroaryl bromides

The reductive cross-coupling of terminal alkenes and N-heterocyclic bromides has been demonstrated by ligand optimization of Pd and CuH catalysis. The optimized ligands are Briphos, a π-acceptor monodentate phosphorus ligand, for Pd catalysis and DTB-DPPBz, a sterically bulky bidentate phosphorus ligand, for CuH catalysis. These conditions were further applied to the gram-scale production of clathryimine B. This journal is

Ruthenium catalyzed β-selective alkylation of vinylpyridines with aldehydes/ketonesviaN2H4mediated deoxygenative couplings

Umpolung (polarity reversal) tactics of aldehydes/ketones have greatly broadened carbonyl chemistry by enabling transformations with electrophilic reagents and deoxygenative functionalizations. Herein, we report the first ruthenium-catalyzed β-selective alkylation of vinylpyridines with both naturally abundant aromatic and aliphatic aldehyde/ketonesviaN2H4mediated deoxygenative couplings. Compared with one-electron umpolung of carbonyls to alcohols, this two-electron umpolung strategy realized reductive deoxygenation targets, which were not only applicable to the regioselective alkylation of a broad range of 2/4-alkene substituted pyridines, but also amenable to challenging 3-vinyl and steric-embedded internal pyridines as well as their analogous heterocyclic structures.

Aryl-Nickel-Catalyzed Benzylic Dehydrogenation of Electron-Deficient Heteroarenes

This manuscript describes the first practical benzylic dehydrogenation of electron-deficient heteroarenes, including pyridines, pyrazines, pyrimidines, pyridazines, and triazines. This transformation allows for the efficient benzylic oxidation of heteroarenes to afford heterocyclic styrenes by the action of nickel catalysis paired with an unconventional bromothiophene oxidant.