211371-10-7

Basic information

• Product Name: N-(2,2-diethoxy-2-pyridin-3-yl-ethyl)-2-(4-nitro-phenyl)-acetamide
• CAS NO: 211371-10-7
• Molecular Weight: 373.409
• Mol File: 211371-10-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(2,2-diethoxy-2-pyridin-3-yl-ethyl)-2-(4-nitro-phenyl)-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,2-diethoxy-2-pyridin-3-yl-ethyl)-2-(4-nitro-phenyl)-acetamide(211371-10-7)
• EPA Substance Registry System: N-(2,2-diethoxy-2-pyridin-3-yl-ethyl)-2-(4-nitro-phenyl)-acetamide(211371-10-7)

Safety Data

• Hazardous Substances Data: 211371-10-7(Hazardous Substances Data)

Upstream product

• 104-03-0 4-nitrobenzeneacetic acid 
• 107445-24-9 2,2-diethoxy-2-(3-pyridyl)ethylamine dihydrochloride 
• 350-03-8 methyl-3-pyridylketone 
• 106881-77-0 (E)-1-(pyridin-3-yl)ethanone oxime 

Downstream Products

• 202873-14-1 2-(4-nitro-phenyl)-N-(2-oxo-2-pyridin-3-yl-ethyl)-acetamide 
• 202873-16-3 2-(4-{4-[4-(3-cyclopentyl-propyl)-5-oxo-4,5-dihydro-tetrazol-1-yl]-benzenesulfonylamino}-phenyl)-N-(2-hydroxy-2-pyridin-3-yl-ethyl)-acetamide 
• 202873-15-2 N-(2-hydroxy-2-pyridin-3-yl-ethyl)-2-(4-nitro-phenyl)-acetamide 
• 211371-13-0 2-(4-amino-phenyl)-N-(2-hydroxy-2-pyridin-3-yl-ethyl)-acetamide 
• 173901-95-6 L 770644 

Relevant articles and documents

Practical chemoenzymatic synthesis of a 3-pyridylethanolamino β3 adrenergic receptor agonist

A chemoenzymatic synthesis of β3 agonist 1 suitable for large scale preparation is described. The key chiral 3-pyridylethanolamine intermediate (R)-7 was prepared via an improved Neber rearrangement and a yeast-mediated asymmetric reduction. The tetrazolone fragment of the molecule was constructed via a dipolar cycloaddition between 1-(cyclopentyl)-3-propylazide and p-chlorosulfonyl phenylisocyanate. Sulfonamide coupling of these two intermediates under Shotten-Baumann conditions, followed by a borane reduction of the amide afforded 1 in 20-32% overall yield from 3-acetylpyridine.