202873-16-3

Basic information

• Product Name: 2-(4-{4-[4-(3-cyclopentyl-propyl)-5-oxo-4,5-dihydro-tetrazol-1-yl]-benzenesulfonylamino}-phenyl)-N-(2-hydroxy-2-pyridin-3-yl-ethyl)-acetamide
• Synonyms: 2-(4-{4-[4-(3-cyclopentyl-propyl)-5-oxo-4,5-dihydro-tetrazol-1-yl]-benzenesulfonylamino}-phenyl)-N-(2-hydroxy-2-pyridin-3-yl-ethyl)-acetamide
• CAS NO: 202873-16-3
• Molecular Weight: 605.718
• Mol File: 202873-16-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4-{4-[4-(3-cyclopentyl-propyl)-5-oxo-4,5-dihydro-tetrazol-1-yl]-benzenesulfonylamino}-phenyl)-N-(2-hydroxy-2-pyridin-3-yl-ethyl)-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-{4-[4-(3-cyclopentyl-propyl)-5-oxo-4,5-dihydro-tetrazol-1-yl]-benzenesulfonylamino}-phenyl)-N-(2-hydroxy-2-pyridin-3-yl-ethyl)-acetamide(202873-16-3)
• EPA Substance Registry System: 2-(4-{4-[4-(3-cyclopentyl-propyl)-5-oxo-4,5-dihydro-tetrazol-1-yl]-benzenesulfonylamino}-phenyl)-N-(2-hydroxy-2-pyridin-3-yl-ethyl)-acetamide(202873-16-3)

Safety Data

• Hazardous Substances Data: 202873-16-3(Hazardous Substances Data)

Upstream product

• 182251-92-9 4-[(3-cyclopentylpropyl)-5-oxo-4,5-dihydrotetrazol-1-yl]phenylsulfonyl chloride 
• 211371-13-0 2-(4-amino-phenyl)-N-(2-hydroxy-2-pyridin-3-yl-ethyl)-acetamide 
• 350-03-8 methyl-3-pyridylketone 
• 106881-77-0 (E)-1-(pyridin-3-yl)ethanone oxime 
• 140-77-2 3-cyclopentylpropionic acid 
• 767-05-5 3-cyclopentyl-1-propanol 
• 6752-38-1 4-chlorosulfonylbenzene isocyanate 
• 107445-24-9 2,2-diethoxy-2-(3-pyridyl)ethylamine dihydrochloride 
• 197146-49-9 1-(cyclopentyl)-3-propylazide 
• 197146-48-8 methanesulfonic acid 3-cyclopentyl-propyl ester 
• 121-57-3 4-aminobenzene sulfonic acid 
• 211371-10-7 N-(2,2-diethoxy-2-pyridin-3-yl-ethyl)-2-(4-nitro-phenyl)-acetamide 
• 202873-15-2 N-(2-hydroxy-2-pyridin-3-yl-ethyl)-2-(4-nitro-phenyl)-acetamide 
• 202873-14-1 2-(4-nitro-phenyl)-N-(2-oxo-2-pyridin-3-yl-ethyl)-acetamide 

Downstream Products

• 173901-95-6 L 770644 

Relevant articles and documents

Practical chemoenzymatic synthesis of a 3-pyridylethanolamino β3 adrenergic receptor agonist

A chemoenzymatic synthesis of β3 agonist 1 suitable for large scale preparation is described. The key chiral 3-pyridylethanolamine intermediate (R)-7 was prepared via an improved Neber rearrangement and a yeast-mediated asymmetric reduction. The tetrazolone fragment of the molecule was constructed via a dipolar cycloaddition between 1-(cyclopentyl)-3-propylazide and p-chlorosulfonyl phenylisocyanate. Sulfonamide coupling of these two intermediates under Shotten-Baumann conditions, followed by a borane reduction of the amide afforded 1 in 20-32% overall yield from 3-acetylpyridine.