211565-05-8

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 169619-48-1 p-nitrocinnamyl alcohol 
• 2609-49-6 diethyl p-nitrobenzylphosphonate 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 619-73-8 4-nitrobenzyl chloride 
• 555-16-8 4-nitrobenzaldehdye 
• 110-89-4 piperidine 
• 99-99-0 1-methyl-4-nitrobenzene 
• 104-03-0 4-nitrobenzeneacetic acid 
• 2124-31-4 4'-dimethylaminoacetophenone 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 2844-15-7 N,N-dimethyl-4-[(E)-2-(4-nitrophenyl)vinyl]aniline 
• 70207-45-3 (4-nitrobenzyl)phosphoric acid diethyl ester 
• 100-14-1 4-nitrobenzyl chloride 

Downstream Products

• 14064-72-3 cis-4-Nitro-4'-dimethylaminostilben 
• 1446410-80-5 4-(dimethylamino)-2-((4-((E)-2-(4-(dimethylamino)styryl))phenylamino)methyl)phenol 
• 22525-43-5 4-amino-4′-(N,N-dimethylamino)stilbene 
• 1229570-63-1 C₂₃H₂₉N₇S₂ 

Relevant academic research and scientific papers

Nonlinear optical properties of diaromatic stilbene, butadiene and thiophene derivatives

Series of highly polar stilbene (1a-e), diphenylbutadiene (2a-c) and phenylethenylthiophene (3a-c) derivatives were preparedviaHorner-Wadsworth-Emmons method with a view to produce new and efficient materials for second harmonic generation (SHG) in the so

Novel photochrome aptamer switch assay (PHASA) for adaptive binding to aptamers

A novel Photochrome-Aptamer Switch Assay (PHASA) for the detection and quantification of small environmentally important molecules such as toxins, explosives, drugs and pollutants, which are difficult to detect using antibodies-based assays with high sensitivity and specificity, has been developed. The assay is based on the conjugation of a particular stilbene-analyte derivative to any aptamer of interest. A unique feature of the stilbene molecule is its reporting power via trans-cis photoisomerisation (from fluorescent trans-isomer to non-fluorescent cis-isomer) upon irradiation with the excitation light. The resulting fluorescence decay rate for the trans-isomer of the stilbene-analyte depends on viscosity and spatial freedom to rotate in the surrounding medium and can be used to indicate the presence of the analyte. Quantification of the assay is achieved by calibration of the fluorescence decay rate for the amount of the tested analyte. Two different formats of PHASA have been recently developed: direct conjugation and adaptive binding. New stilbene-maleimide derivatives used in the adaptive binding format have been prepared and characterised. They demonstrate effective binding to the model thiol compound and to the thiolated Malachite Green aptamer.

Rhenium(i) complexes of N-heterocyclic carbene ligands that bind to amyloid plaques of Alzheimer's disease

A series of [Re(i)L(CO)3]+ complexes (where L is a bifunctional bis(NHC)-amine ligand) that are analogues of potential Tc-99m diagnostic imaging agents for Alzheimer's disease have been synthesised. One of the complexes bound to amyl

A joint theoretical and experimental insight into the electronic structure of chromophores derived from 6H,12H-5,11-methano-dibenzo[b,f][1,5]diazocine

We report on the synthesis and electronic spectra of the chiral, donor-acceptor (push-pull) chromophores (±)-4 and (±)-5 with a 6H,12H-5,11-methanodibenzo[b,f][1,5]diazocine scaffold (Scheme 1 and Fig. 2). The electronic structures of these compounds were investigated at a quantum-chemical level (Figs. 2 and 3). The chemical reactivity of 6H,12H-5,11-methanodibenzo[b,f][1,5]diazocine ((±)-11) towards aromatic electrophilic substitution (Scheme 2 and Table) provided additional information about its electronic structure and confirmed nonnegligible derealization of the lone pair of the bridge-head N-atoms in this heterocyclic system.

Excited state intramolecular proton transfer of new diphenylethylene derivatives bearing imino group: A combination of experimental and theoretical investigation

In this paper, we described the synthesis and characterization of new diphenylethylene bearing imino group. We concentrated particularly on the investigation of the possibility of the excited state intramolecular charge transfer (ESIPT) of the new dyes ex

Copper Bis(thiosemicarbazonato)-stilbenyl Complexes That Bind to Amyloid-β Plaques

Alzheimer's disease is characterized by the presence of extracellular amyloid-β plaques. Positron emission tomography (PET) imaging with tracers radiolabeled with positron-emitting radionuclides that bind to amyloid-β plaques can assist in the diagnosis o

Charge neutral rhenium tricarbonyl complexes of tridentate N-heterocyclic carbene ligands that bind to amyloid plaques of Alzheimer's disease

Two tridentate ligand systems bearing N-heterocyclic carbene (NHC), amine and carboxylate donor groups coupled to benzothiazole- or stilbene-based amyloid binding moieties were synthesised. Reaction of the imidazolium salt containing pro-ligands with Re(CO)5Cl yielded the corresponding rhenium metal complexes which were characterised by NMR, and X-ray crystallography. These ligands are of interest for the potential preparation of technetium-99m imaging agents for Alzheimer's disease and the capacity of these rhenium complexes bind to amyloid fibrils composed of amyloid-β peptide and amyloid plaques in human frontal cortex brain tissue was evaluated using fluorescence microscopy. These studies show that the complexes bound efficiently to amyloid-β fibrils and some evidence of binding to amyloid-β plaques.

Molecular probes for imaging of myelin

A molecular probe for labeling myelin includes a fluorescent trans-stilbene derivative.

Theoretical and Experimental Studies of N,N-Dimethyl-N′-Picryl-4,4′-Stilbenediamine

N,N-dimethyl-N′-picryl-4,4′-stilbenediamine (DMPSDA) was prepared, purified and crystallised in a form of black lustrous crystals, and its absorption and fluorescence spectra were recorded in cyclohexane, acetonitrile and dimethyl sulfoxide. Non-emissive

New organic conjugated dye nano-aggregates exhibiting naked-eye fluorescence color switching

In this study, a variety of new conjugated containing strong electron-donating groups were prepared for formation of organic nano-scale aggregates. The properties and aggregation modes of these aggregates were investigated on basis of time dependent absorption, fluorescence emission spectra as well as scanning electron microscope images. The results show that nano organic aggregates could be yielded by the linear dyes in mixed DMF/H2O solvent through a simple re-precipitation method, while no aggregates of the branched dyes were produced. X-ray diffraction of single crystal and X-ray diffraction patterns of the powders results demonstrate that the linear dyes tend to show ordered molecular arrangements, while the armed dyes do not exhibit such a tendency. A remarkable fluorescence switching process under 365 nm lamp was observed for the target aggregates. This study successfully provides real examples of organic aggregates in mixed DMF/H2O solvent which have great capacity to show enhanced fluorescence color switching.