2116-41-8Relevant articles and documents
Four Simultaneously Dynamic Covalent Reactions. Experimental Proof of Orthogonality
Seifert, Helen M.,Ramirez Trejo, Karina,Anslyn, Eric V.
, p. 10916 - 10924 (2016)
Dynamic covalent reactions are widely used in dynamic combinatorial chemistry. Most of these reactions are run under differing reaction conditions and exhibit cross-reactivity when components of multiple reactions are present in one reaction vessel. Herei
A Versatile, Traceless C-H Activation-Based Approach for the Synthesis of Heterocycles
Zhou, Shuguang,Wang, Jinhu,Zhang, Feifei,Song, Chao,Zhu, Jin
supporting information, p. 2427 - 2430 (2016/06/09)
A versatile, traceless C-H activation-based approach for the synthesis of diversified heterocycles is reported. Rh(III)-catalyzed, N-amino-directed C-H alkenylation generates either olefination products or indoles (in situ annulation) in an atom- and step-economic manner at room temperature. The remarkable reactivity endowed by this directing group enables scale-up of the reaction to a 10 g scale at a very low catalyst loading (0.01 mol %/0.1 mol %). Ex situ annulation of olefination product provides entry into an array of heterocycles.
Syntheses and antitumor activities of N′1, N′3-dialkyl-N′1,N′3-di- (alkylcarbonothioyl) malonohydrazide: The discovery of elesclomol
Chen, Shoujun,Sun, Lijun,Koya, Keizo,Tatsuta, Noriaki,Xia, Zhiqiang,Korbut, Timothy,Du, Zhenjian,Wu, Jim,Liang, Guiqing,Jiang, Jun,Ono, Mitsunori,Zhou, Dan,Sonderfan, Andrew
, p. 5070 - 5076 (2013/09/12)
A series of N′1,N′3-dialkyl- N′1,N′3-di(alkylcarbonothioyl) malonohydrazides have been designed and synthesized as anticancer agents by targeting oxidative stress and Hsp70 induction. Structure-activity relationship (SAR) studies lead to the discovery of STA-4783 (elesclomol), a novel small molecule that has been evaluated in a number of clinical trials as an anticancer agent in combination with Taxol.
Discovery of ectoparasiticidal hydrazonotrifluoromethanesulfonanilides
Ali, Abdelselam,Fisara, Petr,Freemont, Jamie A.,Kyi, Stella,Meyer, Adam G.,Riches, Andrew G.,Sargent, Roger M.,Sawutz, David G.,Turner, Kathleen A.,Winzenberg, Kevin N.,Yang, Qi
experimental part, p. 649 - 652 (2010/06/12)
A series of hydrazonotrifluorosulfonanilide derivatives were synthesized and evaluated for in vitro activity against the ectoparasites Ctenocephalides felis and Rhipicephalus sanguineus. Some compounds with excellent activity against tick were identified.
N-PHENYL-1,1,1-TRIFLUOROMETHANESULFONAMIDE HYDRAZONE DERIVATIVE COMPOUNDS AND THEIR USAGE IN CONTROLLING PARASITES
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Page/Page column 37, (2008/06/13)
Novel N-phenyl-1,1,1-trifluoromethanesulfonamide compounds useful for controlling endo and/or ectoparasites in the environment are provided, together with methods of making the same, and methods of using the inventive compounds to treat parasite infestations in vivo and ex vivo.
Optimizing the reversibility of hydrazone formation for dynamic combinatorial chemistry
Nguyen, Regis,Huc, Ivan
, p. 942 - 943 (2007/10/03)
Hydrazones from hydrazines bearing electron withdrawing groups, and aromatic or aliphatic aldehydes form and hydrolyse rapidly in water at neutral pH.
Oxidation of 2-phenylhydrazono-γ-butyrolactone: A novel ring expansion rearrangement leading to tetrahydro-1,3-oxazine-2,4-dione derivatives
Barton, Derek H. R.,Liu, Wansheng
, p. 571 - 572 (2007/10/03)
2-Hydroxy-2-phenylazo-γ-butyrolactone 3a, prepared from oxidation of phenylhydrazone 1a, either decomposes to form α-keto-γ-butyrolactone 2a in 80% yield or rearranges to tetrahydro-1,3-oxazine-2,4-dione derivative 4a in 95% yield under different conditio
