21165-16-2

Basic information

• Product Name: Benzeneacetamide, -alpha--hydroxy-4-methoxy-
• Synonyms: Benzeneacetamide, -alpha--hydroxy-4-methoxy-
• CAS NO: 21165-16-2
• Molecular Formula: C₉H₁₁NO₃
• Molecular Weight: 181.19
• Mol File: 21165-16-2.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzeneacetamide, -alpha--hydroxy-4-methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetamide, -alpha--hydroxy-4-methoxy-(21165-16-2)
• EPA Substance Registry System: Benzeneacetamide, -alpha--hydroxy-4-methoxy-(21165-16-2)

Safety Data

• Hazardous Substances Data: 21165-16-2(Hazardous Substances Data)

Upstream product

• 13305-14-1 methyl 2-hydroxy-2-(4-methoxyphenyl)acetate 
• 935764-11-7 2-(4-methoxyphenyl)-2-oxoacetamide 
• 7099-91-4 p-methoxybenzoylformic acid 
• 117177-66-9 2-(4-methoxyphenyl)-2-oxoacetyl chloride 
• 32174-38-2 methyl (R)-2-hydroxy-2-(4-methoxyphenyl)acetate 
• 7664-41-7 ammonia 
• 123-11-5 4-methoxy-benzaldehyde 
• 79-06-1 2-propenamide 
• 20714-90-3 4-Methoxymandelic acid 
• 104383-29-1 methyl (S)-α-hydroxy-(4-methoxyphenyl)acetate 
• 7647-01-0 hydrogenchloride 
• 33646-40-1 4-methoxymandelonitrile 

Downstream Products

• 119341-75-2 1-hydroxy-1-<(4-methoxy)-phenyl>-2-propanone 
• 848-11-3 5-(4-methoxy-phenyl)-2,2-bis-trifluoromethyl-oxazolidin-4-one 
• 835-59-6 5-(4-methoxy-phenyl)-2,2-dimethyl-oxazolidin-4-one 
• 17159-27-2 5-(4-methoxyphenyl)-2-morpholinooxazol-4(5H)-one 
• 17159-28-3 2-(dimethylamino)-5-(4-methoxyphenyl)oxazol-4(5H)-one 
• 14021-70-6 5-(4-methoxyphenyl)-2-(piperidin-1-yl)oxazol-4(5H)-one 
• 1889-84-5 4'-methoxybenzoin 
• 99309-85-0 1-hydroxy-1-(4-methoxyphenyl)-2-butanone 
• 20714-90-3 4-Methoxymandelic acid 

Relevant articles and documents

α-ZrP/Uracil/Cu2+ nanoparticles as an efficient catalyst in the Morita-Baylis-Hillman reaction

A facile synthesis of uracil-Cu2+ nanoparticles immobilized on alpha-zirconium hydrogen phosphate (α-ZrP), abbreviated as α-ZrP/Uracil/Cu2+, was presented. This compound was synthesized by the thermal method and used as a reusable ca

Condensation of vilsmeier salts, derived from tetraalkylureas, with α-hydroxy amide derivatives: One-pot approach to synthesize 2-dialkylamino-2-oxazolin-4-ones

A novel and straightforward synthetic protocol was developed to synthesize 2-dialkylamino-2-oxazolin-4-ones from various Vilsmeier salts and α-hydroxy amides derivatives. Notably, thozalinone (3a), as a mild stimulant in tristimania and anorexic, could be synthesized simply and in a high yield using this methodology.

Hemilability-Driven Water Activation: A NiII Catalyst for Base-Free Hydration of Nitriles to Amides

The NiII complex 1 containing pyridyl- and hydroxy-functionalized N-heterocyclic carbenes (NHCs) is synthesized and its catalytic utility for the selective nitrile hydration to the corresponding amide under base-free conditions is evaluated. The title compound exploits a hemilabile pyridyl unit to interact with a catalytically relevant water molecule through hydrogen-bonding and promotes a nucleophilic water attack to the nitrile. A wide variety of nitriles is hydrated to the corresponding amides including the pharmaceutical drugs rufinamide, Rifater, and piracetam. Synthetically challenging α-hydroxyamides are accessed from cyanohydrins under neutral conditions. Related catalysts that lack the pyridyl unit (i.e., compounds 2 and 4) are not active whereas those containing both the pyridyl and the hydroxy or only the pyridyl pendant (i.e., compounds 1 and 3) show substantial activity. The linkage isomer 1′ where the hydroxy group is bound to the metal instead of the pyridyl group was isolated under different crystallization conditions insinuating a ligand hemilabile behavior. Additional pKa measurements reveal an accessible pyridyl unit under the catalytic conditions. Kinetic studies support a ligand-promoted nucleophilic water addition to a metal-bound nitrile group. This work reports a Ni-based catalyst that exhibits functional hemilability for hydration chemistry.