21165-16-2

Upstream product

• 33646-40-1 4-methoxymandelonitrile 
• 20714-90-3 4-Methoxymandelic acid 
• 123-11-5 4-methoxy-benzaldehyde 
• 79-06-1 2-propenamide 
• 32174-38-2 methyl (R)-2-hydroxy-2-(4-methoxyphenyl)acetate 
• 7664-41-7 ammonia 
• 935764-11-7 2-(4-methoxyphenyl)-2-oxoacetamide 
• 7099-91-4 p-methoxybenzoylformic acid 
• 117177-66-9 2-(4-methoxyphenyl)-2-oxoacetyl chloride 
• 104383-29-1 methyl (S)-α-hydroxy-(4-methoxyphenyl)acetate 
• 7647-01-0 hydrogenchloride 
• 13305-14-1 methyl 2-hydroxy-2-(4-methoxyphenyl)acetate 

Downstream Products

• 119341-75-2 1-hydroxy-1-<(4-methoxy)-phenyl>-2-propanone 
• 848-11-3 5-(4-methoxy-phenyl)-2,2-bis-trifluoromethyl-oxazolidin-4-one 
• 835-59-6 5-(4-methoxy-phenyl)-2,2-dimethyl-oxazolidin-4-one 
• 20714-90-3 4-Methoxymandelic acid 
• 17159-28-3 2-(dimethylamino)-5-(4-methoxyphenyl)oxazol-4(5H)-one 
• 14021-70-6 5-(4-methoxyphenyl)-2-(piperidin-1-yl)oxazol-4(5H)-one 
• 17159-27-2 5-(4-methoxyphenyl)-2-morpholinooxazol-4(5H)-one 
• 1889-84-5 4'-methoxybenzoin 
• 99309-85-0 1-hydroxy-1-(4-methoxyphenyl)-2-butanone 

Relevant academic research and scientific papers

α-ZrP/Uracil/Cu2+ nanoparticles as an efficient catalyst in the Morita-Baylis-Hillman reaction

A facile synthesis of uracil-Cu2+ nanoparticles immobilized on alpha-zirconium hydrogen phosphate (α-ZrP), abbreviated as α-ZrP/Uracil/Cu2+, was presented. This compound was synthesized by the thermal method and used as a reusable ca

Bifunctional organometallic catalysts for selective hydration of nitriles to amides

In this report, we highlight our recent contributions towards the development of bifunctional catalysts for selective hydration of nitriles to amides.

SUBSTITUTED PYRIDINES AS INHIBITORS OF DNMT1

The invention is directed to substituted pyridine derivatives. Specifically, the invention is directed to compounds according to Formula (Iar): (Iar) wherein Yar, X1ar, X2ar, R1ar, R2ar, R3ar, R4ar and R5ar are as defined herein; or a pharmaceutically acceptable salt or prodrug thereof. The compounds of the invention are selective inhibitors of DNMT1 and can be useful in the treatment of cancer, pre-cancerous syndromes, beta hemoglobinopathy disorders, sickle cell disease, sickle cell anemia, and beta thalassemia, and diseases associated with DNMT1 inhibition. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting DNMT1 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Condensation of vilsmeier salts, derived from tetraalkylureas, with α-hydroxy amide derivatives: One-pot approach to synthesize 2-dialkylamino-2-oxazolin-4-ones

A novel and straightforward synthetic protocol was developed to synthesize 2-dialkylamino-2-oxazolin-4-ones from various Vilsmeier salts and α-hydroxy amides derivatives. Notably, thozalinone (3a), as a mild stimulant in tristimania and anorexic, could be synthesized simply and in a high yield using this methodology.

Hemilability-Driven Water Activation: A NiII Catalyst for Base-Free Hydration of Nitriles to Amides

The NiII complex 1 containing pyridyl- and hydroxy-functionalized N-heterocyclic carbenes (NHCs) is synthesized and its catalytic utility for the selective nitrile hydration to the corresponding amide under base-free conditions is evaluated. The title compound exploits a hemilabile pyridyl unit to interact with a catalytically relevant water molecule through hydrogen-bonding and promotes a nucleophilic water attack to the nitrile. A wide variety of nitriles is hydrated to the corresponding amides including the pharmaceutical drugs rufinamide, Rifater, and piracetam. Synthetically challenging α-hydroxyamides are accessed from cyanohydrins under neutral conditions. Related catalysts that lack the pyridyl unit (i.e., compounds 2 and 4) are not active whereas those containing both the pyridyl and the hydroxy or only the pyridyl pendant (i.e., compounds 1 and 3) show substantial activity. The linkage isomer 1′ where the hydroxy group is bound to the metal instead of the pyridyl group was isolated under different crystallization conditions insinuating a ligand hemilabile behavior. Additional pKa measurements reveal an accessible pyridyl unit under the catalytic conditions. Kinetic studies support a ligand-promoted nucleophilic water addition to a metal-bound nitrile group. This work reports a Ni-based catalyst that exhibits functional hemilability for hydration chemistry.

Biocatalytic reduction of α-keto amides to (R)-α-hydroxy amides using Candida parapsilosis ATCC 7330

Biocatalytic reduction of primary and secondary α-keto amides was accomplished using whole cells of Candida parapsilosis ATCC 7330. The primary (R)-α-hydroxy amides were obtained in good enantiomeric excess (up to 94%) and conversion (88-99%) as compared to the secondary (R)-α-hydroxy amides.