21190-93-2Relevant articles and documents
Electrocatalytic Water Oxidation by a Tetranuclear Copper Complex
Praneeth, Vijayendran K. K.,Kondo, Mio,Woi, Pei Meng,Okamura, Masaya,Masaoka, Shigeyuki
, p. 1123 - 1128 (2016)
A novel tetranuclear copper-based water oxidation catalyst was designed and synthesized by using a new multinucleating ligand containing two proton dissociation sites, 1,3-bis(6-hydroxy-2-pyridyl)-1H-pyrazole. The copper complex showed electrocatalytic activity for water oxidation reactions under aqueous basic conditions (pH 12.5) with an overpotential of approximately 500 mV. UV/Vis absorption and energy-dispersive X-ray (EDX) spectroscopic techniques coupled with electrochemical analyses of the catalyst system strongly suggest that the tetranuclear copper complex works as a homogeneous system under the conditions used. The results described here demonstrate the utility of a discrete tetranuclear copper complex in water oxidation reactions.
SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF CANCERS, INCLUDING HEPATOCELLULAR CARCINOMA, AND AS INHIBITORS OF HEPATITIS VIRUS REPLICATION
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Paragraph 0140; 0141; 0144; 0145, (2013/04/24)
Pharmaceutical compositions of the invention are presented which comprise substiuted aminothiazoles derivatives. The substiuted aminothiazoles derivatives have a disease-modifying action in the treatment of diseases associated with unregulated cell growth. Such diseases include cancers such as hepatocellular carcinoma, and viral infections from a hepatitis virus.
TRIAZOLOPYRIDINES. PART 8. NUCLEOPHILIC SUBSTITUTION REACTIONS OF 5-BROMOTRIAZOLOISOQUINOLINE AND 7-BROMO-TRIAZOLOPYRIDINE
Abarca, Belen,Mojarred, Fatemeh,Jones, Gurnos,Phillips, Caroline,NG, Nadine,Wastling, Jonathan
, p. 3005 - 3014 (2007/10/02)
Nucleophilic substitution of 5-bromotriazoloisoquinoline (3) and of 7-bromo-3-methyltriazolopyridine (6) proceeds readily to give a range of 5-substituted triazoloisoquinolines (4a)-(4e), and of 7-substituted triazolopyridines (7a)-(7h) respectively.Triazoloisoquinolines have been converted into 1,3-disubstituted isoquinolines (11)-(13), (15), and (16), and triazolopyridines into 2,6-disubstituted pyridines (17)-(19).Of secondary amine nucleophiles, only piperidine reacted with 7-bromo-3-methyl-triazolopyridine (6) to give the 7-substituted derivative (7g).A second product in this reaction was a 2,6-disubstituted pyridine (8); the similar compounds (20)-(24) were the only products when morpholine or N-acetyl-piperazine were used.The reaction between 7-bromotriazolopyridine (9) and piperidine or morpholine gave in high yield the 2,6-disubstituted pyridines (25) and (26).