211949-57-4

Basic information

• Product Name: 2-Thio-1,3-oxazolo[4,5-b]pyridine
• Synonyms: 2-Thio-1,3-oxazolo[4,5-b]pyridine
• CAS NO: 211949-57-4
• Molecular Formula: C6H4N2OS
• Molecular Weight: 152.17376
• Mol File: 211949-57-4.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 284.1°C at 760 mmHg
• Flash Point: 125.6°C
• Appearance: /
• Density: 1.53g/cm³
• Vapor Pressure: 0.00303mmHg at 25°C
• Refractive Index: 1.729
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 2.91±0.50(Predicted)
• CAS DataBase Reference: 2-Thio-1,3-oxazolo[4,5-b]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thio-1,3-oxazolo[4,5-b]pyridine(211949-57-4)
• EPA Substance Registry System: 2-Thio-1,3-oxazolo[4,5-b]pyridine(211949-57-4)

Safety Data

• Hazardous Substances Data: 211949-57-4(Hazardous Substances Data)

Usage

Description

2-Thio-1,3-oxazolo[4,5-b]pyridine is a heterocyclic chemical compound with the molecular formula C6H5NOS. It features a unique structure that incorporates both sulfur and nitrogen atoms, making it a compound of interest in the fields of medicinal chemistry and chemical synthesis. Its potential pharmacological properties have been a focus of study for its application in pharmaceuticals, as well as its utility as a building block in the synthesis of other compounds.

Uses

Used in Pharmaceutical Applications:
2-Thio-1,3-oxazolo[4,5-b]pyridine is utilized as a pharmaceutical agent due to its potential pharmacological properties. Its unique structure allows it to be a candidate for the development of new drugs, particularly in the area of medicinal chemistry where its specific interactions with biological targets can be explored.
Used in Organic Synthesis:
In the field of chemical synthesis, 2-Thio-1,3-oxazolo[4,5-b]pyridine serves as a valuable building block. It is used for the preparation of various other compounds, contributing to the diversity of chemical libraries and facilitating the discovery of new molecules with specific applications in different industries.
While the provided materials do not specify particular industries or reasons for the applications, the general uses outlined above reflect the compound's relevance in the broader scope of chemical and medicinal research and development. If more specific applications are identified in future research, they can be added to the list accordingly.

InChI:InChI=1/C6H4N2OS/c10-6-8-5-4(9-6)2-1-3-7-5/h1-3H,(H,7,8,10)

Upstream product

• 16867-03-1 2-amino-3-hydroxypyridine 
• 140-89-6 potassium ethyl xanthogenate 
• 75-15-0 carbon disulfide 
• 137-26-8 Thiram 

Downstream Products

• 325976-45-2 2-chlorooxazolo[4,5-b]pyridine 
• 931321-16-3 2-morpholino-6-nitrooxazolo[4,5-b]pyridine 
• 113520-22-2 1-(oxazolo[4,5-b]pyridin-2-yl)piperazine 
• 300672-80-4 2-(3H-oxazolo[4,5-b]pyridin-2-ylideneamino)-ethanethiol 
• 169205-95-2 2-(methylthio)oxazolo[4,5-b]pyridine 

Relevant articles and documents

Discovery of CA-4948, an Orally Bioavailable IRAK4 Inhibitor for Treatment of Hematologic Malignancies

Small molecule potent IRAK4 inhibitors from a novel bicyclic heterocycle class were designed and synthesized based on hits identified from Aurigene's compound library. The advanced lead compound, CA-4948, demonstrated good cellular activity in ABC DLBCL and AML cell lines. Inhibition of TLR signaling leading to decreased IL-6 levels was also observed in whole blood assays. CA-4948 demonstrated moderate to high selectivity in a panel of 329 kinases as well as exhibited desirable ADME and PK profiles including good oral bioavailability in mice, rat, and dog and showed >90% tumor growth inhibition in relevant tumor models with excellent correlation with in vivo PD modulation. CA-4948 was well tolerated in toxicity studies in both mouse and dog at efficacious exposure. The overall profile of CA-4948 prompted us to select it as a clinical candidate for evaluation in patients with relapsed or refractory hematologic malignancies including non-Hodgkin lymphoma and acute myeloid leukemia.

Compounds for Pain Treatment, Compositions Comprising Same, and Methods of Using Same

The invention relates to compounds of formula (I), compositions containing the same, and methods for treating and/or diminishing pain in a subject in need thereof. The compounds of formula (I) are effective for treating opioid-induced tachyphylaxis and op

An environmentally benign and efficient synthesis of substituted benzothiazole-2-thiols, benzoxazole-2-thiols, and benzimidazoline-2-thiones in water

An efficient and practical method for the one-step synthesis of benzothiazole-2-thiols, benzoxazole-2-thiols and benzimidazoline-2-thiones by cyclization of 2-aminothiophenols, 2-aminophenols, and 1,2-phenylenediamines with tetramethylthiuram disulfide (TMTD) in water was described. The features of this method include metal/ligand-free, excellent yield, short reaction time and broad substrate scope. The method provides a facile and convenient preparation of some potentially biologically active compounds.