212002-75-0Relevant academic research and scientific papers
A new synthesis of chiral aminoalkyloxazolecarboxylate esters from isoxazol-5(2H)-ones: The synthesis of almazoles A and B
Khalafy, Jabbar,Svensson, Carina E.,Prager, Rolf H.,Williams, Craig M.
, p. 5405 - 5408 (1998)
2-(1-Aminoalkyl)oxazole-4 and 5-carboxylates are available, without detectable racemisation, by a sequence involving N-acylation of isoxazol- 5(2H)one carboxylates with phthalimidoamino acids, photolysis of the acylated product, and hydrazinolysis. An application of the procedure to the synthesis of almazole A and B is described.
The synthesis of some chiral 2-aminoalkyloxazole-5-carboxylates from isoxazol-5(2H)-ones
Cox, Matthew,Prager, Rolf H.,Svensson, Carina E.,Taylor, Max R.
, p. 897 - 901 (2007/10/03)
Ethyl 5-oxo-2,5-dihydroisoxazole-4-carboxylates have been N-acylated by a number of natural and synthetic phthalimidylamino acids in the presence of carbodiimides. The N-acylated products form the corresponding 2-aminoalkyloxazole-5-carboxylates smoothly when irradiated at 300 nm in acetone.
