146037-86-7

Basic information

• Product Name: 3-methyl-5-oxo-2,5-dihydro-isoxazole-4-carboxylic acid ethyl ester
• Synonyms: 3-methyl-5-oxo-2,5-dihydro-isoxazole-4-carboxylic acid ethyl ester
• CAS NO: 146037-86-7
• Molecular Weight: 171.153
• Mol File: 146037-86-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-methyl-5-oxo-2,5-dihydro-isoxazole-4-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methyl-5-oxo-2,5-dihydro-isoxazole-4-carboxylic acid ethyl ester(146037-86-7)
• EPA Substance Registry System: 3-methyl-5-oxo-2,5-dihydro-isoxazole-4-carboxylic acid ethyl ester(146037-86-7)

Safety Data

• Hazardous Substances Data: 146037-86-7(Hazardous Substances Data)

Upstream product

• 570-08-1 diethyl acetylmalonate 
• 5456-14-4 3,5-diethoxy-carbonyl-2,6-dimethyl-4H-pyran-4-one 
• 3044-06-2 diethyl 2-(1-ethoxyethylidene)malonate 

Downstream Products

• 212002-75-0 ethyl 2-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanoyl]-3-methyl-5-oxo-2,5-dihydroisoxazole-4-carboxylate 
• 7697-37-2 nitric acid 
• 144-62-7 oxalic acid 
• 7782-77-6 cis-nitrous acid 
• 64-19-7 acetic acid 

Relevant articles and documents

The Chemistry of 5-Oxodihydroisoxazoles. II. Photolysis and Pyrolysis of 2-(Isoquinolin-1-yl)-3-methyl-5-oxo-2,5-dihydroisoxazole-4-carboxylate

Photolysis of ethyl 2-(isoquinolin-1-yl)-3-methyl-5-oxo-2,5-dihydroisoxazole-4-carboxylate occurs by two pathways.The major pathway involves the loss of CO2 to form an imino carbene which may cyclize to form the expected (6) or rearranged (8) imidazoisoquinolines or react with nucleophiles and recyclize to form the 4-oxopyrimidoisoquinolines.The minor pathway involves electrocyclic ring opening of the isoxazolone and ring closure with or without loss of CO.Pyrolysis leads predominantly to an imino carbene which reacts intramolecularly to give (6) or undergoes insertion into CH bonds.