21205-08-3

Upstream product

• 614-47-1 1,3-diphenyl-propen-3-one 
• 75-08-1 ethanethiol 
• 94-41-7 benzalacetophenone 
• 850998-07-1 2-acetyl-3,3-bis-ethylsulfanyl-N-o-tolyl-acrylamide 
• 98-86-2 acetophenone 
• 100-52-7 benzaldehyde 

Downstream Products

• 94-41-7 benzalacetophenone 
• 74408-96-1 1,3-diphenyl-3-phenylsulfanyl-propan-1-one 
• 5350-97-0 1,3-diphenyl-3-piperidin-1-yl-propan-1-one 

Relevant academic research and scientific papers

A mild and highly efficient one-pot three-component reaction for carbon-sulfur bond formation catalyzed by potassium tert-butoxide

Potassium tert-butoxide has been found to be a highly efficient catalyst for one-pot, three-component reaction of aryl aldehydes, acetophenones, and thiols via Claisen-Schmidt/Michael addition reactions for the synthesis of thia-Michael adducts in high yields. The reactions are best carried out in tert-butyl alcohol at room temperature.

A bifunctional cinchona alkaloid-squaramide catalyst for the highly enantioselective conjugate addition of thiols to transchalcones

A chiral squaramide catalysts-promoted asymmetric sulfa-Michael conjugated addition of thiols to trans-chalcones is presented. Moderate to excellent yields and high enantioselectivities (up to 99% ee) were achieved under mild conditions.

Amino acid catalyzed thio-Michael addition reactions

Using amino acid as a catalyst, an inexpensive, nontoxic, environmentally friendly, metal-free reaction procedure for C-S bond formation via thio-Michael addition reaction has been developed. The thio-Michael addition products were obtained in excellent yields under mild and neutral conditions. This metal-free catalytic protocol was found to be a good alternative to the existing metal catalyst methodology for the thio-Michael addition reaction.

Borax as an efficient metal-free catalyst for hetero-Michael reactions in an aqueous medium

Borax, a naturally occurring material, very efficiently catalyzed the conjugate addition of thiols, dithiols and amines to α,β-unsaturated ketones, nitriles, amides, aldehydes and esters in an aqueous medium to afford the corresponding Michael adducts in good yields at room temperature. Recycling of the catalyst and scaling up of the reactions are important attributes of this catalysis. The reactions of thiols and dithiols were relatively more facile than those of the corresponding amines. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.

Scope and limitations of HClO4-SiO2 as an extremely efficient, inexpensive, and reusable catalyst for chemoselective carbon-sulfur bond formation

The scope and limitations of perchloric acid adsorbed on silica gel (HClO4-SiO2) as a highly efficient, inexpensive, and reusable catalyst for chemoselective carbon-sulfur bond formation by conjugate addition of thiols to α,β-unsatur

Thia-Michael addition reactions using 2-[bis(alkylthio)methylene]-3-oxo-N- o-tolylbutanamides as odorless and efficient thiol equivalents

A series of 2-[bis(alkylthio)methylene]-3-oxo-N-o-tolylbutanamides 1 have been investigated as nonthiolic and odorless thiol equivalents in thia-Michael addition reactions. The cleavage of compounds 1 is initiated by NaOH in EtOH; the in situ generated th

Perchloric acid impregnated on silica gel (HClO4/SiO 2): A versatile catalyst for Michael addition of thiols to the electron-deficient alkenes

Perchloric acid adsorbed on silica gel (HClO4X/SiO2) has been found to be a highly efficient and versatile catalyst for the Michael addition of thiols to a wide variety of conjugated alkenes such as α,α-unsaturated ketones, carboxylic esters, nitriles, amides and chalcones in dichloromethane or methanol at room temperature. The reactions are completed within 2-20 min in high yields. Some of the additional advantages are: no aqueous work-up is necessary, and the catalyst is also reusable. Moreover, the solid product can be obtained without chromatographic separation. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.

Zinc perchlorate hexahydrate catalysed conjugate addition of thiols to α,β-unsaturated ketones

Zn(II) perchlorate hexahydrate has been found to be a new and efficient catalyst for conjugate addition of thiols to α,β-unsaturated ketones under solvent-free conditions at room temperature. The reaction of aryl, arylalkyl and alkyl thiols with cyclic an

Copper(II) tetrafluoroborate as a novel and highly efficient catalyst for Michael addition of mercaptans to α,β-unsaturated carbonyl compounds

Copper(II) tetrafluoroborate has been found to be a new and highly efficient catalyst for Michael addition of thiols to α,β-unsaturated carbonyl compounds under solvent-free conditions and in H2O at room temperature. The reactions are very fast