5350-97-0Relevant academic research and scientific papers
Microwave solvent-free synthesis of nitrocyclohexanols
Correc, Olivier,Guillou, Karine,Hamelin, Jack,Paquin, Ludovic,Texier-Boullet, Fran?oise,Toupet, Lo?c
, p. 391 - 395 (2004)
New nitrocyclohexanols 3a-f are synthesized by a clean and original method from nitromethane 1 and unsaturated ketones 2a-f in the presence of solid potassium fluoride-alumina under solvent-free conditions coupled with microwave irradiation. The reaction involves a double and diastereoselective Michael addition followed by ring closure. Another diastereomer 3′, which differs by the configuration of C-4, is obtained in the presence of piperidine and EtOH at room temperature.
Highly efficient one-pot, three-component synthesis of β-aminoketones catalyzed by Fe(O2CCF3)3
Zhang, Min,Xiong, Biao,Yang, Wei,Chen, Ling,Wu, Feng,Wang, Quan,Ding, Yuqiang
experimental part, p. 2831 - 2843 (2012/07/27)
(Chemical Equation Presented) A highly efficient one-pot, three-component synthesis of β-aminoketones was demonstrated using the cost-effective, noncorrosive, and easily available Fe(O2CCF3)3 as a catalyst for the first time. The method can be employed to synthesize a wide range of target compounds and to introduce different functional groups into the β-aminoketone skeleton. Additionally, the method consistently has the advantages of good yields, short reaction time, and simply experimental workup procedure, which makes it a useful process for the synthesis of functionalized β-aminoketones. Copyright Taylor & Francis Group, LLC.
An efficient and improved synthesis of 1,5-diketones: versatile conjugate addition of nucleophiles to α,β-unsaturated enones and alkynones
Shankar, Ravi,Jha, Ashok K.,Singh, Uma Sharan,Hajela
, p. 3077 - 3079 (2007/10/03)
Several 1,5-diketones have been prepared in good to excellent yields by versatile conjugate addition of nucleophiles such as cyclic or acyclic ketones, amines and thiols to α,β-unsaturated enones and alkynones, in the presence of catalytic amounts of 10%
Ultrasound-irradiated Michael addition of amines to ferrocenylenones under solvent-free and catalyst-free conditions at room temperature
Yang, Jin-Ming,Ji, Shun-Jun,Gu, Da-Gong,Shen, Zhi-Liang,Wang, Shun-Yi
, p. 2989 - 2995 (2007/10/03)
A facile Michael addition of ferrocenylenones with aliphatic amines under ultrasound irradiation in the absence of solvent and catalyst at room temperature can afford 1-ferrocenyl-3-amino carbonyl compounds rapidly in high yields, which is also efficient in the aza-Michael reaction of other α,β-unsaturated carbonyl compounds such as chalcone, carboxylic ester, etc. However, aromatic amines do not undergo the conjugate addition at all, and the reactions under existing methods do not proceed or take place in low yield after a long reaction time. Apart from experimental simplicity, generality and selectivity, the advantages of this methodology are the rapid, environmentally benign and less expensive processes, which will contribute to the progress of green chemistry.
Water promoted Michael addition of secondary amines: To α,β- unsaturated carbonyl compounds under microwave irradiation
Matloubi Moghaddam, Firouz,Mohammadi, Mohsen,Hosseinnia, Azarmidocht
, p. 643 - 650 (2007/10/03)
A rapid Michael addition of secondary amines to α,β-unsaturated carbonyl compounds has been achieved in good to excellent yields in the presence of water under microwave irradiation. In the absence of water and under conventional method the reaction does not proceed or take place in very low yield after a long reaction time.
A novel method for michael addition and epoxidation of chalcones in a water suspension medium: A completely organic solvent-free synthetic procedure
Toda, Fumio,Takumi, Hideaki,Nagami, Masuhiro,Tanaka, Kenya
, p. 469 - 479 (2007/10/03)
Very efficient Michael addition reactions of amines, thiophenol and methyl acetylacetate to chalcone, and epoxidation of chalcone derivatives with NaOCl, in a water suspension medium have been developed as completely organic solvent-free reactions.
Diastereoselektive Synthese neuartiger Mannich-Basen mittels Titanderivaten
Seebach, Dieter,Betschart, Claudia,Schiess, Martin
, p. 1593 - 1597 (2007/10/02)
Trichlorotitanium dialkylamino-alkoxides (2; titanates of N,O-hemiacetals) are generated either from the corresponding lithium alkoxides and titanium tetrachloride (Scheme I) or by addition of trichloro-dialkylamino-titanium to aldehydes.The electrophilic
